| Literature DB >> 25486183 |
C K Hind1, M J Carter1, C L Harris1, H T C Chan1, S James1, M S Cragg2.
Abstract
Bfl-1 is a pro-survival Bcl-2 family member overexpressed in a subset of chemoresistant tumours, including melanoma. Here, we characterised the expression and regulation of Bfl-1 in normal and malignant melanocytes and determined its role in protecting these cells from chemotherapy-induced apoptosis. Bfl-1 was mitochondrially resident in both resting and apoptotic cells and experienced regulation by the proteasome and NFκB pathways. siRNA-mediated knockdown enhanced sensitivity towards various relevant drug treatments, with forced overexpression of Bfl-1 protective. These findings identify Bfl-1 as a contributor towards therapeutic resistance in melanoma cells and support the use of NFκB inhibitors alongside current treatment strategies.Entities:
Keywords: Apoptosis; BCL2A1; Bfl-1; Melanocytes; Melanoma
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Year: 2014 PMID： 25486183 DOI： 10.1016/j.biocel.2014.11.015
Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085