Crystal structure of 5-(4,5-di-hydro-1H-imidazol-2-yl)-3-methyl-1-phenyl-1H-pyrazolo-[3,4-b]pyrazin-6-amine.

In the title compound, C15H15N7, the phenyl ring is inclined by 19.86 (5)° to the mean plane of the pyrazolo-[3,4-b]pyrazine core. In the crystal, N-H⋯N and C-H⋯N hydrogen bonds form [010] chains, which stack via π-π inter-actions [centroid-centroid distance between the pyrazole rings = 3.4322 (7) Å].

Related literature

For the synthesis of similar pyrazolo­[3,4-b]pyrazines, see: El-Emary & El-Kashef (2013 ▶). For different biological and industrial applications of pyrazolo­pyrazine scaffold compounds, see: El-Emary et al. (1998 ▶); El-Kashef et al. (2000 ▶); El-Emary (2006 ▶); Rangnekar (1990 ▶).

Experimental

Crystal data

C15H15N7

M = 293.34

Monoclinic,

a = 7.9412 (2) Å

b = 15.7078 (3) Å

c = 22.3276 (4) Å

β = 98.573 (1)°

V = 2754.00 (10) Å3

Z = 8

Cu Kα radiation

μ = 0.75 mm−1

T = 150 K

0.15 × 0.10 × 0.05 mm

Data collection

Bruker D8 VENTURE PHOTON 100 CMOS diffractometer

Absorption correction: multi-scan (SADABS; Bruker, 2014 ▶) T min = 0.93, T max = 0.97

21033 measured reflections

2685 independent reflections

2335 reflections with I > 2σ(I)

R int = 0.031

Refinement

R[F 2 > 2σ(F 2)] = 0.035

wR(F 2) = 0.094

S = 1.04

2685 reflections

201 parameters

H-atom parameters constrained

Δρmax = 0.23 e Å−3

Δρmin = −0.17 e Å−3

Data collection: APEX2 (Bruker, 2014 ▶); cell refinement: SAINT (Bruker, 2014 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXT (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL2014 (Sheldrick, 2008 ▶); molecular graphics: DIAMOND (Brandenburg & Putz, 2012 ▶); software used to prepare material for publication: SHELXTL2014 (Sheldrick, 2008 ▶).

Crystal structure: contains datablock(s) global, I. DOI: 10.1107/S160053681402354X/hg5415sup1.cif

Structure factors: contains datablock(s) I. DOI: 10.1107/S160053681402354X/hg5415Isup2.hkl

Click here for additional data file.

Supporting information file. DOI: 10.1107/S160053681402354X/hg5415Isup3.cml

Click here for additional data file.

. DOI: 10.1107/S160053681402354X/hg5415fig1.tif

The title mol­ecule with numbering scheme and 50% probability ellipsoids. The intra­molecular hydrogen bond is shown as a blue dotted line.

Click here for additional data file.

. DOI: 10.1107/S160053681402354X/hg5415fig2.tif

Plan view of the chain showing N—H⋯N and C—H⋯N hydrogen bonds as blue and black dotted lines, respectively.

Click here for additional data file.

. DOI: 10.1107/S160053681402354X/hg5415fig3.tif

Elevation view of two chains showing the π-π inter­actions as green dotted lines.

Click here for additional data file.

a . DOI: 10.1107/S160053681402354X/hg5415fig4.tif

Packing viewed down the a axis.

CCDC reference: 1031105

Additional supporting information: crystallographic information; 3D view; checkCIF report

C15H15N7	F(000) = 1232
Mr = 293.34	Dx = 1.415 Mg m−3
Monoclinic, C2/c	Cu Kα radiation, λ = 1.54178 Å
a = 7.9412 (2) Å	Cell parameters from 9946 reflections
b = 15.7078 (3) Å	θ = 4.0–71.7°
c = 22.3276 (4) Å	µ = 0.75 mm−1
β = 98.573 (1)°	T = 150 K
V = 2754.00 (10) Å3	Block, colourless
Z = 8	0.15 × 0.10 × 0.05 mm

Bruker D8 VENTURE PHOTON 100 CMOS diffractometer	2685 independent reflections
Radiation source: INCOATEC IµS micro–focus source	2335 reflections with I > 2σ(I)
Mirror monochromator	Rint = 0.031
Detector resolution: 10.4167 pixels mm-1	θmax = 72.0°, θmin = 4.0°
ω scans	h = −9→9
Absorption correction: multi-scan (SADABS; Bruker, 2014)	k = −19→18
Tmin = 0.93, Tmax = 0.97	l = −25→27
21033 measured reflections

Refinement on F2	Secondary atom site location: difference Fourier map
Least-squares matrix: full	Hydrogen site location: mixed
R[F2 > 2σ(F2)] = 0.035	H-atom parameters constrained
wR(F2) = 0.094	w = 1/[σ2(Fo2) + (0.047P)2 + 1.7272P] where P = (Fo2 + 2Fc2)/3
S = 1.04	(Δ/σ)max < 0.001
2685 reflections	Δρmax = 0.23 e Å−3
201 parameters	Δρmin = −0.17 e Å−3
0 restraints	Extinction correction: SHELXL2014 (Sheldrick, 2008), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4
Primary atom site location: structure-invariant direct methods	Extinction coefficient: 0.00012 (3)

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger. H-atoms attached to carbon were placed in calculated positions (C—H = 0.95 - 0.98 Å) while those attached to nitrogen were placed in locations derived from a difference map and their parameters adjusted to give N—H = 0.91 Å. All were included as riding contributions with isotropic displacement parameters 1.2 - 1.5 times those of the attached atoms.

	x	y	z	Uiso*/Ueq
N1	0.21440 (13)	0.23938 (6)	0.22995 (4)	0.0252 (2)
N2	0.24278 (14)	0.15429 (6)	0.24683 (5)	0.0284 (3)
N3	0.49830 (13)	0.27132 (6)	0.36366 (5)	0.0255 (2)
N4	0.31514 (13)	0.37679 (6)	0.27055 (4)	0.0258 (2)
N5	0.43603 (15)	0.49390 (7)	0.32160 (5)	0.0350 (3)
H5A	0.5051	0.5149	0.3545	0.042*
H5B	0.3806	0.5295	0.2931	0.042*
N6	0.62895 (15)	0.47203 (7)	0.43134 (5)	0.0345 (3)
N7	0.69317 (15)	0.33776 (7)	0.46313 (5)	0.0339 (3)
H7A	0.7265	0.2859	0.4511	0.041*
C1	0.10360 (15)	0.25899 (8)	0.17597 (5)	0.0255 (3)
C2	0.03232 (16)	0.33968 (8)	0.16704 (6)	0.0292 (3)
H2	0.0600	0.3829	0.1967	0.035*
C3	−0.07919 (17)	0.35656 (9)	0.11468 (6)	0.0325 (3)
H3	−0.1269	0.4119	0.1083	0.039*
C4	−0.12216 (18)	0.29404 (9)	0.07151 (6)	0.0366 (3)
H4	−0.2016	0.3057	0.0363	0.044*
C5	−0.04798 (19)	0.21408 (9)	0.08019 (6)	0.0382 (3)
H5	−0.0757	0.1711	0.0504	0.046*
C6	0.06600 (18)	0.19648 (8)	0.13184 (6)	0.0322 (3)
H6	0.1183	0.1421	0.1371	0.039*
C7	0.30685 (15)	0.29182 (8)	0.27108 (5)	0.0241 (3)
C8	0.39641 (15)	0.23910 (8)	0.31557 (5)	0.0251 (3)
C9	0.35066 (16)	0.15415 (8)	0.29763 (6)	0.0278 (3)
C10	0.4086 (2)	0.07325 (9)	0.32887 (7)	0.0377 (3)
H10A	0.3465	0.0253	0.3079	0.057*
H10B	0.3866	0.0753	0.3709	0.057*
H10C	0.5309	0.0659	0.3284	0.057*
C11	0.41803 (16)	0.40912 (8)	0.31815 (5)	0.0260 (3)
C12	0.50810 (15)	0.35545 (8)	0.36559 (5)	0.0253 (3)
C13	0.61270 (16)	0.39176 (8)	0.41964 (5)	0.0263 (3)
C14	0.80754 (19)	0.38977 (9)	0.50567 (6)	0.0366 (3)
H14A	0.9268	0.3854	0.4980	0.044*
H14B	0.8018	0.3736	0.5482	0.044*
C15	0.73523 (19)	0.47864 (9)	0.49128 (6)	0.0380 (3)
H15A	0.6658	0.4970	0.5223	0.046*
H15B	0.8283	0.5203	0.4901	0.046*

	U11	U22	U33	U12	U13	U23
N1	0.0278 (5)	0.0214 (5)	0.0242 (5)	−0.0011 (4)	−0.0036 (4)	−0.0001 (4)
N2	0.0326 (6)	0.0213 (5)	0.0288 (6)	−0.0016 (4)	−0.0037 (4)	0.0005 (4)
N3	0.0263 (5)	0.0237 (5)	0.0250 (5)	−0.0011 (4)	−0.0008 (4)	−0.0008 (4)
N4	0.0269 (6)	0.0230 (5)	0.0256 (5)	−0.0006 (4)	−0.0019 (4)	−0.0005 (4)
N5	0.0429 (7)	0.0222 (5)	0.0345 (6)	0.0006 (5)	−0.0123 (5)	−0.0005 (4)
N6	0.0385 (6)	0.0279 (6)	0.0329 (6)	−0.0012 (5)	−0.0082 (5)	−0.0059 (5)
N7	0.0434 (7)	0.0270 (6)	0.0269 (6)	−0.0027 (5)	−0.0087 (5)	−0.0004 (4)
C1	0.0244 (6)	0.0276 (6)	0.0233 (6)	−0.0040 (5)	−0.0007 (5)	0.0017 (5)
C2	0.0300 (7)	0.0289 (7)	0.0269 (6)	0.0004 (5)	−0.0014 (5)	−0.0016 (5)
C3	0.0319 (7)	0.0319 (7)	0.0315 (7)	0.0023 (5)	−0.0024 (6)	0.0031 (5)
C4	0.0370 (7)	0.0396 (8)	0.0289 (7)	−0.0038 (6)	−0.0095 (6)	0.0032 (6)
C5	0.0465 (8)	0.0337 (7)	0.0301 (7)	−0.0065 (6)	−0.0088 (6)	−0.0033 (6)
C6	0.0387 (7)	0.0251 (6)	0.0300 (7)	−0.0030 (5)	−0.0035 (6)	−0.0002 (5)
C7	0.0232 (6)	0.0249 (6)	0.0233 (6)	−0.0013 (5)	0.0009 (5)	−0.0011 (5)
C8	0.0260 (6)	0.0233 (6)	0.0245 (6)	0.0000 (5)	−0.0010 (5)	0.0002 (5)
C9	0.0300 (7)	0.0246 (6)	0.0270 (6)	−0.0013 (5)	−0.0018 (5)	−0.0002 (5)
C10	0.0463 (8)	0.0254 (7)	0.0364 (7)	−0.0021 (6)	−0.0108 (6)	0.0029 (5)
C11	0.0261 (6)	0.0244 (6)	0.0262 (6)	0.0006 (5)	−0.0004 (5)	−0.0016 (5)
C12	0.0251 (6)	0.0243 (6)	0.0253 (6)	−0.0011 (5)	0.0005 (5)	−0.0016 (5)
C13	0.0259 (6)	0.0268 (6)	0.0252 (6)	−0.0011 (5)	0.0007 (5)	−0.0008 (5)
C14	0.0408 (8)	0.0371 (7)	0.0280 (7)	−0.0054 (6)	−0.0075 (6)	−0.0028 (6)
C15	0.0398 (8)	0.0359 (7)	0.0339 (7)	−0.0033 (6)	−0.0089 (6)	−0.0089 (6)

N1—C7	1.3638 (15)	C3—C4	1.3826 (19)
N1—N2	1.3978 (14)	C3—H3	0.9500
N1—C1	1.4161 (16)	C4—C5	1.389 (2)
N2—C9	1.3158 (17)	C4—H4	0.9500
N3—C12	1.3241 (16)	C5—C6	1.3836 (19)
N3—C8	1.3435 (16)	C5—H5	0.9500
N4—C7	1.3365 (16)	C6—H6	0.9500
N4—C11	1.3401 (16)	C7—C8	1.4028 (17)
N5—C11	1.3404 (16)	C8—C9	1.4246 (17)
N5—H5A	0.9100	C9—C10	1.4891 (18)
N5—H5B	0.9099	C10—H10A	0.9800
N6—C13	1.2902 (17)	C10—H10B	0.9800
N6—C15	1.4755 (17)	C10—H10C	0.9800
N7—C13	1.3732 (16)	C11—C12	1.4554 (17)
N7—C14	1.4620 (17)	C12—C13	1.4741 (16)
N7—H7A	0.9099	C14—C15	1.525 (2)
C1—C2	1.3904 (18)	C14—H14A	0.9900
C1—C6	1.3916 (18)	C14—H14B	0.9900
C2—C3	1.3829 (18)	C15—H15A	0.9900
C2—H2	0.9500	C15—H15B	0.9900
C7—N1—N2	110.30 (10)	N3—C8—C7	121.67 (11)
C7—N1—C1	130.20 (10)	N3—C8—C9	132.50 (11)
N2—N1—C1	119.48 (10)	C7—C8—C9	105.83 (11)
C9—N2—N1	106.98 (10)	N2—C9—C8	110.29 (11)
C12—N3—C8	115.30 (10)	N2—C9—C10	121.41 (11)
C7—N4—C11	113.36 (10)	C8—C9—C10	128.29 (11)
C11—N5—H5A	116.9	C9—C10—H10A	109.5
C11—N5—H5B	122.3	C9—C10—H10B	109.5
H5A—N5—H5B	120.8	H10A—C10—H10B	109.5
C13—N6—C15	106.19 (11)	C9—C10—H10C	109.5
C13—N7—C14	107.03 (11)	H10A—C10—H10C	109.5
C13—N7—H7A	118.0	H10B—C10—H10C	109.5
C14—N7—H7A	120.9	N4—C11—N5	117.98 (11)
C2—C1—C6	120.12 (12)	N4—C11—C12	122.21 (11)
C2—C1—N1	120.56 (11)	N5—C11—C12	119.81 (11)
C6—C1—N1	119.31 (11)	N3—C12—C11	122.30 (11)
C3—C2—C1	119.46 (12)	N3—C12—C13	115.85 (11)
C3—C2—H2	120.3	C11—C12—C13	121.83 (11)
C1—C2—H2	120.3	N6—C13—N7	116.00 (11)
C4—C3—C2	120.89 (13)	N6—C13—C12	124.83 (11)
C4—C3—H3	119.6	N7—C13—C12	119.08 (11)
C2—C3—H3	119.6	N7—C14—C15	101.34 (10)
C3—C4—C5	119.33 (12)	N7—C14—H14A	111.5
C3—C4—H4	120.3	C15—C14—H14A	111.5
C5—C4—H4	120.3	N7—C14—H14B	111.5
C6—C5—C4	120.54 (13)	C15—C14—H14B	111.5
C6—C5—H5	119.7	H14A—C14—H14B	109.3
C4—C5—H5	119.7	N6—C15—C14	105.85 (10)
C5—C6—C1	119.60 (13)	N6—C15—H15A	110.6
C5—C6—H6	120.2	C14—C15—H15A	110.6
C1—C6—H6	120.2	N6—C15—H15B	110.6
N4—C7—N1	128.29 (11)	C14—C15—H15B	110.6
N4—C7—C8	125.12 (11)	H15A—C15—H15B	108.7
N1—C7—C8	106.59 (10)
C7—N1—N2—C9	0.15 (14)	N1—N2—C9—C8	−0.06 (15)
C1—N1—N2—C9	179.34 (11)	N1—N2—C9—C10	179.61 (12)
C7—N1—C1—C2	−20.6 (2)	N3—C8—C9—N2	178.77 (13)
N2—N1—C1—C2	160.36 (11)	C7—C8—C9—N2	−0.05 (15)
C7—N1—C1—C6	159.58 (12)	N3—C8—C9—C10	−0.9 (2)
N2—N1—C1—C6	−19.42 (17)	C7—C8—C9—C10	−179.69 (14)
C6—C1—C2—C3	1.55 (19)	C7—N4—C11—N5	179.53 (11)
N1—C1—C2—C3	−178.23 (11)	C7—N4—C11—C12	−0.94 (17)
C1—C2—C3—C4	0.8 (2)	C8—N3—C12—C11	−1.44 (17)
C2—C3—C4—C5	−2.0 (2)	C8—N3—C12—C13	177.08 (10)
C3—C4—C5—C6	0.9 (2)	N4—C11—C12—N3	2.23 (19)
C4—C5—C6—C1	1.4 (2)	N5—C11—C12—N3	−178.24 (12)
C2—C1—C6—C5	−2.6 (2)	N4—C11—C12—C13	−176.20 (11)
N1—C1—C6—C5	177.17 (12)	N5—C11—C12—C13	3.32 (18)
C11—N4—C7—N1	179.70 (12)	C15—N6—C13—N7	0.00 (16)
C11—N4—C7—C8	−0.87 (18)	C15—N6—C13—C12	176.46 (12)
N2—N1—C7—N4	179.34 (12)	C14—N7—C13—N6	−12.26 (16)
C1—N1—C7—N4	0.3 (2)	C14—N7—C13—C12	171.07 (11)
N2—N1—C7—C8	−0.18 (13)	N3—C12—C13—N6	−175.55 (12)
C1—N1—C7—C8	−179.25 (12)	C11—C12—C13—N6	3.0 (2)
C12—N3—C8—C7	−0.33 (17)	N3—C12—C13—N7	0.80 (17)
C12—N3—C8—C9	−178.99 (13)	C11—C12—C13—N7	179.33 (11)
N4—C7—C8—N3	1.63 (19)	C13—N7—C14—C15	17.78 (15)
N1—C7—C8—N3	−178.84 (11)	C13—N6—C15—C14	11.67 (16)
N4—C7—C8—C9	−179.40 (12)	N7—C14—C15—N6	−17.76 (15)
N1—C7—C8—C9	0.14 (13)

D—H···A	D—H	H···A	D···A	D—H···A
C6—H6···N5i	0.95	2.56	3.3483 (17)	140
N5—H5B···N2ii	0.91	2.31	3.1702 (15)	158
N5—H5A···N6	0.91	1.97	2.7111 (15)	138

Table 1

Hydrogen-bond geometry (, )

DHA	DH	HA	D A	DHA
C6H6N5i	0.95	2.56	3.3483(17)	140
N5H5BN2ii	0.91	2.31	3.1702(15)	158
N5H5AN6	0.91	1.97	2.7111(15)	138

Symmetry codes: (i) ; (ii) .