Literature DB >> 10989833

New pyrazolo[3,4-b]pyrazines: synthesis and biological activity.

H S el-Kashef1, T I el-Emary, M Gasquet, P Timon-David, J Maldonado, P Vanelle.   

Abstract

Some new pyrazolo[3,4-b]pyrazines and related heterocycles were synthesized and evaluated for their antifungal and antiparasitic activities. The key intermediate, 6-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyrazine-5-carbonitrile (3) was obtained in a one-pot synthesis via the reaction of 5-amino-3-methyl-4-nitroso-1-phenylpyrazole 2 with malononitrile.

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Year:  2000        PMID： 10989833     DOI： 10.1002/chin.200047151

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  9 in total

Review 1.  5-Aminopyrazole as precursor in design and synthesis of fused pyrazoloazines.

Authors:  Ranjana Aggarwal; Suresh Kumar
Journal:  Beilstein J Org Chem       Date:  2018-01-25       Impact factor: 2.883

2.  Pyridine-based heterocycles. Synthesis of new pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and related heterocycles.

Authors:  Hussein El-Kashef; Abdel-Rahman Farghaly; Ahmed Al-Hazmi; Thierry Terme; Patrice Vanelle
Journal:  Molecules       Date:  2010-04-12       Impact factor: 4.411

3.  Crystal structure of 5-(4,5-di-hydro-1H-imidazol-2-yl)-3-methyl-1-phenyl-1H-pyrazolo-[3,4-b]pyrazin-6-amine.

Authors:  Joel T Mague; Shaaban K Mohamed; Mehmet Akkurt; Talaat I El-Emary; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-10-31

4.  Crystal structure of (E)-N-{[3-methyl-1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazol-4-yl]methyl-idene}hydroxyl-amine.

Authors:  Joel T Mague; Shaaban K Mohamed; Mehmet Akkurt; Talaat I El-Emary; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-10-31

5.  Crystal structure of 3-{5-[3-(4-fluoro-phen-yl)-1-isopropyl-1H-indol-2-yl]-1H-pyrazol-1-yl}indolin-2-one ethanol monosolvate.

Authors:  Md Lutfor Rahman; Ajaykumar D Kulkarni; Mashitah Mohd Yusoff; Huey Chong Kwong; Ching Kheng Quah
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-02-03

6.  Original TDAE strategy using propargylic chloride: rapid access to 1,4-diarylbut-3-ynol derivatives.

Authors:  Manon Roche; Thierry Terme; Patrice Vanelle
Journal:  Molecules       Date:  2013-01-25       Impact factor: 4.411

7.  Manganese(III) acetate-mediated oxidative cyclization of a-methylstyrene and trans-stilbene with b-ketosulfones.

Authors:  Ahlem Bouhlel; Christophe Curti; Clémence Tabelé; Patrice Vanelle
Journal:  Molecules       Date:  2013-04-11       Impact factor: 4.411

8.  Anticancer and Anti-Inflammatory Activities of Some New Pyrazolo[3,4-b]pyrazines.

Authors:  Hussein El-Kashef; Talaat El-Emary; Pierre Verhaeghe; Patrice Vanelle; Maha Samy
Journal:  Molecules       Date:  2018-10-16       Impact factor: 4.411

9.  Multi-component one-pot synthesis and antimicrobial activities of 3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydro-pyrazolo[5,4-b]pyrimidino[5,4-e]pyridine-5-one and related derivatives.

Authors:  Talaat I El-Emary; Shawkat A Abd El-Mohsen
Journal:  Molecules       Date:  2012-12-06       Impact factor: 4.411
  9 in total

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