Literature DB >> 25484547

Galectin-3: a potential target for cancer prevention.

Hafiz Ahmed1, Prasun Guha2, Engin Kaptan2, Gargi Bandyopadhyaya2.   

Abstract

Protein-carbohydrate interactions play significant role in modulating cell-cell and cell-extracellular matrix interactions, which, in turn, mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding protein family, is found multifunctional and is involved in normal growth development as well as cancer progression and metastasis, but the detailed mechanisms of its functions are not well understood. This review discusses its structure, binding properties, transcriptional regulation and roles in homotypic/heterotypic cell adhesion, angiogenesis and apoptosis.

Entities:  

Keywords:  TF-disaccharide; angiogenesis; apoptosis; galectin-3; tumorigenesis

Year:  2011        PMID： 25484547      PMCID： PMC4254724     

Source DB:  PubMed          Journal:  Trends Carbohydr Res


  120 in total

1.  Galectin-3 expression is induced in cirrhotic liver and hepatocellular carcinoma.

Authors:  D K Hsu; C A Dowling; K C Jeng; J T Chen; R Y Yang; F T Liu
Journal:  Int J Cancer       Date:  1999-05-17       Impact factor: 7.396

2.  Expression and function of galectin-3, a beta-galactoside-binding protein in activated T lymphocytes.

Authors:  H G Joo; P S Goedegebuure; N Sadanaga; M Nagoshi; W von Bernstorff; T J Eberlein
Journal:  J Leukoc Biol       Date:  2001-04       Impact factor: 4.962

3.  Galectin-3 phosphorylation is required for its anti-apoptotic function and cell cycle arrest.

Authors:  Tadashi Yoshii; Tomoharu Fukumori; Yuichiro Honjo; Hidenori Inohara; Hyeong-Reh Choi Kim; Avraham Raz
Journal:  J Biol Chem       Date:  2001-11-27       Impact factor: 5.157

4.  CD133(+) human pulmonary adenocarcinoma cells induce apoptosis of CD8(+) T cells by highly expressed galectin-3.

Authors:  Wan Li; Wang Jian-jun; Zhou Xue-Feng; Zhao Feng
Journal:  Clin Invest Med       Date:  2010-02-01       Impact factor: 0.825

5.  Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils.

Authors:  E Feuk-Lagerstedt; E T Jordan; H Leffler; C Dahlgren; A Karlsson
Journal:  J Immunol       Date:  1999-11-15       Impact factor: 5.422

6.  Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3-dependent keratinocyte motility.

Authors:  Yoshinobu Kariya; Chihiro Kawamura; Toshiki Tabei; Jianguo Gu
Journal:  J Biol Chem       Date:  2009-11-25       Impact factor: 5.157

7.  Endogenous lectins from cultured cells: nuclear localization of carbohydrate-binding protein 35 in proliferating 3T3 fibroblasts.

Authors:  I K Moutsatsos; M Wade; M Schindler; J L Wang
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

8.  Involvement of decreased Galectin-3 expression in the pathogenesis and progression of prostate cancer.

Authors:  Axel S Merseburger; Mario W Kramer; Jörg Hennenlotter; Perikles Simon; Judith Knapp; Jörg T Hartmann; Arnulf Stenzl; Jürgen Serth; Markus A Kuczyk
Journal:  Prostate       Date:  2008-01-01       Impact factor: 4.104

Review 9.  Modified citrus pectin anti-metastatic properties: one bullet, multiple targets.

Authors:  Vladislav V Glinsky; Avraham Raz
Journal:  Carbohydr Res       Date:  2008-09-26       Impact factor: 2.104

10.  Duodenal intraepithelial lymphocytes of children with cow milk allergy preferentially bind the glycan-binding protein galectin-3.

Authors:  N Mercer; L Guzman; E Cueto Rua; R Drut; H Ahmed; G R Vasta; M A Toscano; G A Rabinovich; G H Docena
Journal:  Int J Immunopathol Pharmacol       Date:  2009 Jan-Mar       Impact factor: 3.219
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  4 in total

1.  Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression.

Authors:  Seok-Jun Kim; Hyeok-Gu Kang; Kyungeun Kim; Hoyoung Kim; Fredrik Zetterberg; Young Soo Park; Hyun-Soo Cho; Stephen M Hewitt; Joon-Yong Chung; Ulf J Nilsson; Hakon Leffler; Kyung-Hee Chun
Journal:  Gastric Cancer       Date:  2021-04-08       Impact factor: 7.370

2.  Galectin-3 induced by hypoxia promotes cell migration in thyroid cancer cells.

Authors:  Jiaojiao Zheng; Weihui Lu; Cong Wang; Yang Xing; Xiaoning Chen; Zhilong Ai
Journal:  Oncotarget       Date:  2017-09-21

3.  MG-Pe: A Novel Galectin-3 Ligand with Antimelanoma Properties and Adjuvant Effects to Dacarbazine.

Authors:  Stellee M P Biscaia; Cassiano Pires; Francislaine A R Lívero; Daniel L Bellan; Israel Bini; Silvina O Bustos; Renata O Vasconcelos; Alexandra Acco; Marcello Iacomini; Elaine R Carbonero; Martin K Amstalden; Fábio R Kubata; Richard D Cummings; Marcelo Dias-Baruffi; Fernanda F Simas; Carolina C Oliveira; Rilton A Freitas; Célia Regina Cavichiolo Franco; Roger Chammas; Edvaldo S Trindade
Journal:  Int J Mol Sci       Date:  2022-07-11       Impact factor: 6.208

4.  Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, α9 nicotinic acetylcholine receptor and STAT3.

Authors:  Prasun Guha; Gargi Bandyopadhyaya; Swamy K Polumuri; Saranya Chumsri; Padmaja Gade; Dhananjaya V Kalvakolanu; Hafiz Ahmed
Journal:  Breast Cancer Res Treat       Date:  2014-03-26       Impact factor: 4.624
  4 in total

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