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Literature DB >> 19061992

Modified citrus pectin anti-metastatic properties: one bullet, multiple targets.

Abstract

In this minireview, we examine the ability of modified citrus pectin (MCP), a complex water soluble indigestible polysaccharide obtained from the peel and pulp of citrus fruits and modified by means of high pH and temperature treatment, to affect numerous rate-limiting steps in cancer metastasis. The anti-adhesive properties of MCP as well as its potential for increasing apoptotic responses of tumor cells to chemotherapy by inhibiting galectin-3 anti-apoptotic function are discussed in the light of a potential use of this carbohydrate-based substance in the treatment of multiple human malignancies.

Entities: CellLine Chemical Disease Gene Species

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Year: 2008 PMID： 19061992 PMCID： PMC2782490 DOI： 10.1016/j.carres.2008.08.038

Source DB: PubMed Journal: Carbohydr Res ISSN： 0008-6215 Impact factor: 2.104

37 in total

1. Galectin-3 induces endothelial cell morphogenesis and angiogenesis.

Authors: P Nangia-Makker; Y Honjo; R Sarvis; S Akahani; V Hogan; K J Pienta; A Raz
Journal: Am J Pathol Date: 2000-03 Impact factor: 4.307

2. The galectin profile of the endothelium: altered expression and localization in activated and tumor endothelial cells.

Authors: Victor L Thijssen; Sarah Hulsmans; Arjan W Griffioen
Journal: Am J Pathol Date: 2008-01-17 Impact factor: 4.307

3. Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin.

Authors: Pratima Nangia-Makker; Victor Hogan; Yuichiro Honjo; Sara Baccarini; Larry Tait; Robert Bresalier; Avraham Raz
Journal: J Natl Cancer Inst Date: 2002-12-18 Impact factor: 13.506

4. Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis.

Authors: A B Al-Mehdi; K Tozawa; A B Fisher; L Shientag; A Lee; R J Muschel
Journal: Nat Med Date: 2000-01 Impact factor: 53.440

5. The role of Thomsen-Friedenreich antigen in adhesion of human breast and prostate cancer cells to the endothelium.

Authors: V V Glinsky; G V Glinsky; K Rittenhouse-Olson; M E Huflejt; O V Glinskii; S L Deutscher; T P Quinn
Journal: Cancer Res Date: 2001-06-15 Impact factor: 12.701

6. Effects of daily oral administration of quercetin chalcone and modified citrus pectin on implanted colon-25 tumor growth in Balb-c mice.

Authors: A Hayashi; A C Gillen; J R Lott
Journal: Altern Med Rev Date: 2000-12

7. Galectin-3 protects human breast carcinoma cells against nitric oxide-induced apoptosis: implication of galectin-3 function during metastasis.

Authors: B K Moon; Y J Lee; P Battle; J M Jessup; A Raz; H R Kim
Journal: Am J Pathol Date: 2001-09 Impact factor: 4.307

8. Galectin-3 overexpression protects from cell damage and death by influencing mitochondrial homeostasis.

Authors: P Matarrese; N Tinari; M L Semeraro; C Natoli; S Iacobelli; W Malorni
Journal: FEBS Lett Date: 2000-05-19 Impact factor: 4.124

9. Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation.

Authors: Fei Yu; Russell L Finley; Avraham Raz; Hyeong-Reh Choi Kim
Journal: J Biol Chem Date: 2002-02-11 Impact factor: 5.157

Review 10. Dissemination and growth of cancer cells in metastatic sites.

Authors: Ann F Chambers; Alan C Groom; Ian C MacDonald
Journal: Nat Rev Cancer Date: 2002-08 Impact factor: 60.716

57 in total

Review 1. Galectin-3 and cancer stemness.

Authors: Pratima Nangia-Makker; Victor Hogan; Avraham Raz
Journal: Glycobiology Date: 2018-04-01 Impact factor: 4.313

2. Galectin-3 and new-onset CKD: marker or mediator?

Authors: Pietro Ravani; Brendan J Barrett
Journal: J Am Soc Nephrol Date: 2013-06-20 Impact factor: 10.121

3. The inhibitory effects of a rhamnogalacturonan I (RG-I) domain from ginseng pectin on galectin-3 and its structure-activity relationship.

Authors: Xiaoge Gao; Yuan Zhi; Lin Sun; Xiaoxia Peng; Tao Zhang; Huiting Xue; Guihua Tai; Yifa Zhou
Journal: J Biol Chem Date: 2013-10-07 Impact factor: 5.157

Review 4. Nuclear transport of galectin-3 and its therapeutic implications.

Authors: Tatsuyoshi Funasaka; Avraham Raz; Pratima Nangia-Makker
Journal: Semin Cancer Biol Date: 2014-03-19 Impact factor: 15.707

5. Galectin-3 expressed on different lung compartments promotes organ specific metastasis by facilitating arrest, extravasation and organ colonization via high affinity ligands on melanoma cells.

Authors: Manohar C Dange; Nithya Srinivasan; Shyam K More; Sanjay M Bane; Archana Upadhya; Arvind D Ingle; Rajiv P Gude; Rabindranath Mukhopadhyaya; Rajiv D Kalraiya
Journal: Clin Exp Metastasis Date: 2014-06-21 Impact factor: 5.150

6. Galectin-3 is independently associated with cardiovascular mortality in community-dwelling older adults without known cardiovascular disease: The Rancho Bernardo Study.

Authors: Lori B Daniels; Paul Clopton; Gail A Laughlin; Alan S Maisel; Elizabeth Barrett-Connor
Journal: Am Heart J Date: 2014-02-18 Impact factor: 4.749