N K Klimas1, A D Shedd2, I H Bernstein3, H Jacobe1. 1. Department of Dermatology, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX, 75390-9096, U.S.A. 2. ProPath Associates, Dallas, TX, U.S.A. 3. Department of Clinical Science, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX, 75390-9096, U.S.A.
Abstract
BACKGROUND: Little is known about the health-related quality of life (HRQoL) of patients with morphoea, and previous studies have yielded conflicting results. OBJECTIVES: To determine the impact of morphoea on HRQoL, and clinical and demographic correlates of HRQoL in adults. METHODS: This was a cross-sectional survey (n = 73) of the Morphea in Adults and Children cohort. RESULTS: Morphoea impairs HRQoL in adults. Patients were most impaired by emotional well-being and concerns that the disease would progress to internal organs. Patients with morphoea had worse skin-specific HRQoL than those with nonmelanoma skin cancer, vitiligo and alopecia (lowest P < 0·01). Participants had significantly worse global HRQoL scores than the general U.S. population for all subscales (all P < 0·01), with the exception of bodily pain. Comorbidity (r = 0·35-0·51, all P < 0·01), and symptoms of pruritus (r = 0·38-0·64, all P < 0·01) and pain (r = 0·46-0·74, all P < 0·01) were associated with impairment in multiple domains of skin-specific and global HRQoL. Physician-based measures of disease severity correlated with patient-reported HRQoL. CONCLUSIONS: Patients with morphoea experience a negative impact on HRQoL, particularly if symptoms (pruritus and pain) or concerns regarding internal manifestations are present. Providers should be aware of this when evaluating and treating patients.
BACKGROUND: Little is known about the health-related quality of life (HRQoL) of patients with morphoea, and previous studies have yielded conflicting results. OBJECTIVES: To determine the impact of morphoea on HRQoL, and clinical and demographic correlates of HRQoL in adults. METHODS: This was a cross-sectional survey (n = 73) of the Morphea in Adults and Children cohort. RESULTS:Morphoea impairs HRQoL in adults. Patients were most impaired by emotional well-being and concerns that the disease would progress to internal organs. Patients with morphoea had worse skin-specific HRQoL than those with nonmelanoma skin cancer, vitiligo and alopecia (lowest P < 0·01). Participants had significantly worse global HRQoL scores than the general U.S. population for all subscales (all P < 0·01), with the exception of bodily pain. Comorbidity (r = 0·35-0·51, all P < 0·01), and symptoms of pruritus (r = 0·38-0·64, all P < 0·01) and pain (r = 0·46-0·74, all P < 0·01) were associated with impairment in multiple domains of skin-specific and global HRQoL. Physician-based measures of disease severity correlated with patient-reported HRQoL. CONCLUSIONS:Patients with morphoea experience a negative impact on HRQoL, particularly if symptoms (pruritus and pain) or concerns regarding internal manifestations are present. Providers should be aware of this when evaluating and treating patients.
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