Literature DB >> 25482988

PLC and PI3K/Akt/mTOR signalling in disease and cancer.

Matilde Y Follo1, Lucia Manzoli2, Alessandro Poli2, James A McCubrey3, Lucio Cocco4.   

Abstract

Cancer cell metabolism is deregulated, and signalling pathways can be involved. For instance, PI3K/Akt/mTOR is associated with normal proliferation and differentiation, and its alteration is detectable in cancer cells, that exploit the normal mechanisms to overcome apoptosis. On the other hand, also the family of Phospholipase C (PLC) enzymes play a critical role in cell growth, and any change concerning these enzymes or their downstream targets can be associated with neoplastic transformation. Here, we review the role of PLC and PI3K/Akt/mTOR signal transduction pathways in pathophysiology.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Nucleus; PI3K/Akt/mTOR; Phospholipase C

Mesh：

Substances：

Year:  2014        PMID： 25482988     DOI： 10.1016/j.jbior.2014.10.004

Source DB:  PubMed          Journal:  Adv Biol Regul        ISSN： 2212-4926


  43 in total

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Review 3.  Phosphoinositide-specific phospholipase C in health and disease.

Authors:  Lucio Cocco; Matilde Y Follo; Lucia Manzoli; Pann-Ghill Suh
Journal:  J Lipid Res       Date:  2015-03-27       Impact factor: 5.922

Review 4.  Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia.

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Review 7.  The Hidden Conundrum of Phosphoinositide Signaling in Cancer.

Authors:  Narendra Thapa; Xiaojun Tan; Suyong Choi; Paul F Lambert; Alan C Rapraeger; Richard A Anderson
Journal:  Trends Cancer       Date:  2016-06-20

8.  Eplerenone attenuates myocardial infarction in diabetic rats via modulation of the PI3K-Akt pathway and phosphorylation of GSK-3β.

Authors:  Umesh B Mahajan; Govind Chandrayan; Chandragouda R Patil; Dharamvir Singh Arya; Kapil Suchal; Yogeeta Agrawal; Shreesh Ojha; Sameer N Goyal
Journal:  Am J Transl Res       Date:  2018-09-15       Impact factor: 4.060

Review 9.  Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros.

Authors:  Chandrika Gowda; Chunhua Song; Malika Kapadia; Jonathon L Payne; Tommy Hu; Yali Ding; Sinisa Dovat
Journal:  Adv Biol Regul       Date:  2016-09-18

Review 10.  Nuclear phospholipase C isoenzyme imbalance leads to pathologies in brain, hematologic, neuromuscular, and fertility disorders.

Authors:  Stefano Ratti; Matilde Y Follo; Giulia Ramazzotti; Irene Faenza; Roberta Fiume; Pann-Ghill Suh; James A McCubrey; Lucia Manzoli; Lucio Cocco
Journal:  J Lipid Res       Date:  2018-10-04       Impact factor: 5.922
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