Literature DB >> 27819060

The Hidden Conundrum of Phosphoinositide Signaling in Cancer.

Narendra Thapa1, Xiaojun Tan2, Suyong Choi1, Paul F Lambert3, Alan C Rapraeger4, Richard A Anderson5.   

Abstract

Phosphoinositide 3-kinase (PI3K) generation of PI(3,4,5)P3 from PI(4,5)P2 and the subsequent activation of Akt and its downstream signaling cascades (e.g. mTORC1) dominates the landscape of phosphoinositide signaling axis in cancer research. However, PI(4,5)P2 is breaking its boundary as merely a substrate for PI3K and phospholipase C (PLC), and is now an established lipid messenger pivotal for different cellular events in cancer. Here, we review the phosphoinositide signaling axis in cancer, giving due weight to PI(4,5)P2 and its generating enzymes, the phosphatidylinositol phosphate (PIP) kinases (PIPKs). We highlighted how PI(4,5)P2 and PIP kinases serve as a proximal node in phosphoinositide signaling axis and how its interaction with cytoskeletal proteins regulates migratory and invasive nexus of metastasizing tumor cells.

Entities:  

Keywords:  Akt; PI(3,4,5)P3; PI(4,5)P2; PI3K; PIPKIγ

Mesh：

Substances：

Year:  2016        PMID： 27819060      PMCID： PMC5094282          DOI： 10.1016/j.trecan.2016.05.009

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  87 in total

Review 1.  PIP4K and the role of nuclear phosphoinositides in tumour suppression.

Authors:  Roberta Fiume; Yvette Stijf-Bultsma; Zahid H Shah; Willem Jan Keune; David R Jones; Julian Georg Jude; Nullin Divecha
Journal:  Biochim Biophys Acta       Date:  2015-02-26

2.  PI(4,5)P2 produced by the PI4P5K SKTL controls apical size by tethering PAR-3 in Drosophila epithelial cells.

Authors:  Sandra Claret; Julie Jouette; Béatrice Benoit; Kevin Legent; Antoine Guichet
Journal:  Curr Biol       Date:  2014-04-24       Impact factor: 10.834

Review 3.  The functions and regulation of the PTEN tumour suppressor.

Authors:  Min Sup Song; Leonardo Salmena; Pier Paolo Pandolfi
Journal:  Nat Rev Mol Cell Biol       Date:  2012-04-04       Impact factor: 94.444

Review 4.  Idelalisib: A Novel PI3Kδ Inhibitor for Chronic Lymphocytic Leukemia.

Authors:  Arpita Shah; Abhishek Mangaonkar
Journal:  Ann Pharmacother       Date:  2015-07-16       Impact factor: 3.154

5.  Genomic analysis of metastasis reveals an essential role for RhoC.

Authors:  E A Clark; T R Golub; E S Lander; R O Hynes
Journal:  Nature       Date:  2000-08-03       Impact factor: 49.962

Review 6.  PI3K and cancer: lessons, challenges and opportunities.

Authors:  David A Fruman; Christian Rommel
Journal:  Nat Rev Drug Discov       Date:  2014-02       Impact factor: 84.694

Review 7.  Mutations in phosphoinositide metabolizing enzymes and human disease.

Authors:  Heather J McCrea; Pietro De Camilli
Journal:  Physiology (Bethesda)       Date:  2009-02

8.  Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer.

Authors:  Mark G Waugh
Journal:  J Cancer       Date:  2014-10-28       Impact factor: 4.207

9.  Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer.

Authors:  Yue Sun; Dmitry A Turbin; Kun Ling; Narendra Thapa; Samuel Leung; David G Huntsman; Richard A Anderson
Journal:  Breast Cancer Res       Date:  2010-01-14       Impact factor: 6.466

10.  Targeting type Iγ phosphatidylinositol phosphate kinase inhibits breast cancer metastasis.

Authors:  C Chen; X Wang; X Xiong; Q Liu; Y Huang; Q Xu; J Hu; G Ge; K Ling
Journal:  Oncogene       Date:  2014-12-08       Impact factor: 9.867
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  19 in total

Review 1.  Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention.

Authors:  Lisa M Butler; Ylenia Perone; Jonas Dehairs; Leslie E Lupien; Vincent de Laat; Ali Talebi; Massimo Loda; William B Kinlaw; Johannes V Swinnen
Journal:  Adv Drug Deliv Rev       Date:  2020-07-23       Impact factor: 15.470

Review 2.  Polyphosphoinositide-Binding Domains: Insights from Peripheral Membrane and Lipid-Transfer Proteins.

Authors:  Joshua G Pemberton; Tamas Balla
Journal:  Adv Exp Med Biol       Date:  2019       Impact factor: 2.622

Review 3.  The impact of phosphoinositide 5-phosphatases on phosphoinositides in cell function and human disease.

Authors:  Ana Raquel Ramos; Somadri Ghosh; Christophe Erneux
Journal:  J Lipid Res       Date:  2018-09-07       Impact factor: 5.922

4.  Phosphatidylinositol-3-OH kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4.

Authors:  Narendra Thapa; Mo Chen; Hudson T Horn; Suyong Choi; Tianmu Wen; Richard A Anderson
Journal:  Nat Cell Biol       Date:  2020-11-02       Impact factor: 28.824

Review 5.  Calmodulin and PI3K Signaling in KRAS Cancers.

Authors:  Ruth Nussinov; Guanqiao Wang; Chung-Jung Tsai; Hyunbum Jang; Shaoyong Lu; Avik Banerjee; Jian Zhang; Vadim Gaponenko
Journal:  Trends Cancer       Date:  2017-02-18

Review 6.  Phosphoinositide spatially free AKT/PKB activation to all membrane compartments.

Authors:  Narendra Thapa; Hudson Tyler Horn; Richard A Anderson
Journal:  Adv Biol Regul       Date:  2019-04-11

Review 7.  Expanding role of PI5P4Ks in cancer: A promising druggable target.

Authors:  Gurpreet K Arora; Lavinia Palamiuc; Brooke M Emerling
Journal:  FEBS Lett       Date:  2021-12-07       Impact factor: 3.864

8.  Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor.

Authors:  Sospeter N Njeru; Johann Kraus; Jitendra K Meena; Hans A Kestler; Cagatay Günes; K Lenhard Rudolph; André Lechel; Sarah-Fee Katz; Mukesh Kumar; Uwe Knippschild; Anca Azoitei; Felix Wezel; Christian Bolenz; Frank Leithäuser; André Gollowitzer; Omid Omrani; Christian Hoischen; Andreas Koeberle
Journal:  Oncogene       Date:  2019-10-28       Impact factor: 8.756

9.  Nuclear Phosphatidylinositol-Phosphate Type I Kinase α-Coupled Star-PAP Polyadenylation Regulates Cell Invasion.

Authors:  Sudheesh A P; Rakesh S Laishram
Journal:  Mol Cell Biol       Date:  2018-02-12       Impact factor: 4.272

10.  Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.

Authors:  Chuan Chen; Qingwen Xu; Yuxia Zhang; Brian A Davies; Yan Huang; David J Katzmann; Peter C Harris; Jinghua Hu; Kun Ling
Journal:  Sci Adv       Date:  2021-06-23       Impact factor: 14.136
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