Literature DB >> 25482633

Regulation of the protein stability of EMT transcription factors.

V M Díaz1, R Viñas-Castells, A García de Herreros.   

Abstract

The epithelial to mesenchymal transition (EMT) consists of a rapid change of cell phenotype, characterized by the loss of epithelial characteristics and the acquisition of a more invasive phenotype. Transcription factors regulating EMT (Snail, Twist and Zeb) are extremely labile proteins, rapidly degraded by the proteasome system. In this review we analyze the current mechanisms controlling degradation of EMT transcription factors, focusing on the role of new E3 ubiquitin-ligases involved in EMT. We also summarize the regulation of the stability of these EMT transcription factors, specially observed in different stress conditions, such as hypoxia, chemotherapeutic drugs, oxidative stress or γ-irradiation.

Entities:  

Keywords:  EMT; F-box; Snail1; hypoxia; proteasome; stress; ubiquitination

Mesh：

Substances：

Year:  2014        PMID： 25482633      PMCID： PMC4594480          DOI： 10.4161/19336918.2014.969998

Source DB:  PubMed          Journal:  Cell Adh Migr        ISSN： 1933-6918            Impact factor:   3.405


  138 in total

1.  Slug stability is dynamically regulated during neural crest development by the F-box protein Ppa.

Authors:  Ann E Vernon; Carole LaBonne
Journal:  Development       Date:  2006-08-03       Impact factor: 6.868

2.  Nuclear localization signals of the E-cadherin transcriptional repressor Snail.

Authors:  Hyeonseok Ko; Hyun Sil Kim; Nam Hee Kim; Sang Hwy Lee; Kun Hong Kim; Su Hyung Hong; Jong In Yook
Journal:  Cells Tissues Organs       Date:  2007       Impact factor: 2.481

Review 3.  Complex networks orchestrate epithelial-mesenchymal transitions.

Authors:  Jean Paul Thiery; Jonathan P Sleeman
Journal:  Nat Rev Mol Cell Biol       Date:  2006-02       Impact factor: 94.444

Review 4.  Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

Authors:  Héctor Peinado; David Olmeda; Amparo Cano
Journal:  Nat Rev Cancer       Date:  2007-05-17       Impact factor: 60.716

5.  Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis.

Authors:  Maria Escrivà; Sandra Peiró; Nicolás Herranz; Patricia Villagrasa; Natàlia Dave; Bàrbara Montserrat-Sentís; Stephen A Murray; Clara Francí; Thomas Gridley; Ismo Virtanen; Antonio García de Herreros
Journal:  Mol Cell Biol       Date:  2008-01-02       Impact factor: 4.272

6.  Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail.

Authors:  Stefan Grotegut; Dietrich von Schweinitz; Gerhard Christofori; François Lehembre
Journal:  EMBO J       Date:  2006-07-13       Impact factor: 11.598

7.  Stabilization of Snail by HuR in the process of hydrogen peroxide induced cell migration.

Authors:  Rui Dong; Jian-Guo Lu; Qing Wang; Xian-Li He; Yan-Kui Chu; Qing-Jiu Ma
Journal:  Biochem Biophys Res Commun       Date:  2007-03-05       Impact factor: 3.575

8.  A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.

Authors:  Jong In Yook; Xiao-Yan Li; Ichiro Ota; Casey Hu; Hyun Sil Kim; Nam Hee Kim; So Young Cha; Joo Kyung Ryu; Yoon Jung Choi; Jin Kim; Eric R Fearon; Stephen J Weiss
Journal:  Nat Cell Biol       Date:  2006-10-29       Impact factor: 28.824

Review 9.  Function of the zinc-finger transcription factor SNAI2 in cancer and development.

Authors:  César Cobaleda; María Pérez-Caro; Carolina Vicente-Dueñas; Isidro Sánchez-García
Journal:  Annu Rev Genet       Date:  2007       Impact factor: 16.830

10.  Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis.

Authors:  Pascale Leroy; Keith E Mostov
Journal:  Mol Biol Cell       Date:  2007-03-07       Impact factor: 4.138
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  38 in total

1.  EMT reversal in human cancer cells after IR knockdown in hyperinsulinemic mice.

Authors:  Zara Zelenko; Emily Jane Gallagher; Irini Markella Antoniou; Deepali Sachdev; Anupma Nayak; Douglas Yee; Derek LeRoith
Journal:  Endocr Relat Cancer       Date:  2016-07-19       Impact factor: 5.678

2.  Nanoparticle-mediated down-regulation of TWIST increases radiosensitivity of nasopharyngeal carcinoma cells via ERK pathway.

Authors:  Xianlu Zhuo; Aoshuang Chang; Chuang Huang; Li Yang; Houyu Zhao; Yongzhong Wu; Qi Zhou
Journal:  Am J Cancer Res       Date:  2015-03-15       Impact factor: 6.166

3.  Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells.

Authors:  Zhan Shi; Ding Wu; Run Tang; Xiang Li; Renfu Chen; Song Xue; Chengjing Zhang; Xiaoqing Sun
Journal:  J Biosci       Date:  2016-06       Impact factor: 1.826

4.  A Switch in Akt Isoforms Is Required for Notch-Induced Snail1 Expression and Protection from Cell Death.

Authors:  Alex Frías; Guillem Lambies; Rosa Viñas-Castells; Catalina Martínez-Guillamon; Natàlia Dave; Antonio García de Herreros; Víctor M Díaz
Journal:  Mol Cell Biol       Date:  2015-12-28       Impact factor: 4.272

5.  Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis.

Authors:  Qi Sun; Jacqueline Lesperance; Hiromi Wettersten; Elaine Luterstein; Yoko S DeRose; Alana Welm; David A Cheresh; Jay S Desgrosellier
Journal:  J Clin Invest       Date:  2017-12-11       Impact factor: 14.808

6.  Beyond epithelial-to-mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma.

Authors:  L F Loffredo; H Abdala-Valencia; K R Anekalla; L Cuervo-Pardo; C J Gottardi; S Berdnikovs
Journal:  Allergy       Date:  2017-07-06       Impact factor: 13.146

Review 7.  Epithelial-to-Mesenchymal Transition Signaling Pathways Responsible for Breast Cancer Metastasis.

Authors:  Busra Buyuk; Sha Jin; Kaiming Ye
Journal:  Cell Mol Bioeng       Date:  2021-09-02       Impact factor: 3.337

8.  Expression and clinical significance of SNAI1 and ZEB1 genes in acute myeloid leukemia patients.

Authors:  Wafaa Ghoneim Shousha; Shimaa Shawki Ramadan; Abeer Salah El-Saiid; Ahmed Essmat Abdelmoneim; Marwa Ahmed Abbas
Journal:  Mol Biol Rep       Date:  2019-05-04       Impact factor: 2.316

9.  SPSB3 targets SNAIL for degradation in GSK-3β phosphorylation-dependent manner and regulates metastasis.

Authors:  Y Liu; H Zhou; R Zhu; F Ding; Y Li; X Cao; Z Liu
Journal:  Oncogene       Date:  2017-10-23       Impact factor: 9.867

10.  TGFβ-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1.

Authors:  Guillem Lambies; Martina Miceli; Catalina Martínez-Guillamon; Rubén Olivera-Salguero; Raúl Peña; Carolina-Paola Frías; Irene Calderón; Boyko S Atanassov; Sharon Y R Dent; Joaquín Arribas; Antonio García de Herreros; Víctor M Díaz
Journal:  Cancer Res       Date:  2018-10-19       Impact factor: 13.312
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