May A Beydoun1, Marie T Fanelli-Kuczmarski, Melissa H Kitner-Triolo, Hind A Beydoun, Jay S Kaufman, Marc A Mason, Michele K Evans, Alan B Zonderman. 1. From the National Institute on Aging (M.A.B., M.H.K.-T., M.K.E., A.B.Z.), NIA/NIH/IRP, Baltimore, Maryland; Department of Behavioral Health and Nutrition (M.T.F.-K.), University of Delaware, Newark, Delaware; Graduate Program in Public Health (H.A.B.), Eastern Virginia Medical School, Norfolk, Virginia; Department of Epidemiology, Biostatistics, and Occupational Health, (J.S.K.) McGill University, Montreal, Quebec, Canada; and Statistical Information Systems (M.A.M.), MedStar Research Institute, Baltimore, Maryland.
Abstract
BACKGROUND: Dietary antioxidants can inhibit reactions accompanying neurodegeneration and thus prevent cognitive impairment. We describe associations of dietary antioxidants with cognitive function in a large biracial population, while testing moderation by sex, race, and age and mediation by depressive symptoms. METHODS: This was a cross-sectional analysis of 1274 adults (541 men and 733 women) aged 30 to 64 years at baseline (mean [standard deviation] = 47.5 [9.3]) in the Healthy Aging in Neighborhoods of Diversity Across the Lifespan Study, Baltimore city, MD. Cognitive performance in the domains of memory, language/verbal, attention, spatial, psychomotor speed, executive function, and global mental status were assessed. The 20-item Center for Epidemiologic Studies Depression Scale was used to measure depressive symptoms. Dietary intake was assessed with two 24-hour recalls, estimating daily consumption of total carotenoids and vitamins A, C, and E per 1000 kcal. RESULTS: Among key findings, 1 standard deviation (∼ 2.02 mg/1000 kcal) higher vitamin E was associated with a higher score on verbal memory, immediate recall (β = +0.64 [0.19], p = .001), and better language/verbal fluency performance (β = +0.53 [0.16], p = .001), particularly among the younger age group. Women with higher vitamin E intake (β = +0.68 [0.21], p = .001) had better performance on a psychomotor speed test. The vitamin E-verbal memory association was partially mediated by depressive symptoms (proportion mediated = 13%-16%). CONCLUSIONS: In sum, future cohort studies and dietary interventions should focus on associations of dietary vitamin E with cognitive decline, specifically for domains of verbal memory, verbal fluency, and psychomotor speed.
BACKGROUND: Dietary antioxidants can inhibit reactions accompanying neurodegeneration and thus prevent cognitive impairment. We describe associations of dietary antioxidants with cognitive function in a large biracial population, while testing moderation by sex, race, and age and mediation by depressive symptoms. METHODS: This was a cross-sectional analysis of 1274 adults (541 men and 733 women) aged 30 to 64 years at baseline (mean [standard deviation] = 47.5 [9.3]) in the Healthy Aging in Neighborhoods of Diversity Across the Lifespan Study, Baltimore city, MD. Cognitive performance in the domains of memory, language/verbal, attention, spatial, psychomotor speed, executive function, and global mental status were assessed. The 20-item Center for Epidemiologic Studies Depression Scale was used to measure depressive symptoms. Dietary intake was assessed with two 24-hour recalls, estimating daily consumption of total carotenoids and vitamins A, C, and E per 1000 kcal. RESULTS: Among key findings, 1 standard deviation (∼ 2.02 mg/1000 kcal) higher vitamin E was associated with a higher score on verbal memory, immediate recall (β = +0.64 [0.19], p = .001), and better language/verbal fluency performance (β = +0.53 [0.16], p = .001), particularly among the younger age group. Women with higher vitamin E intake (β = +0.68 [0.21], p = .001) had better performance on a psychomotor speed test. The vitamin E-verbal memory association was partially mediated by depressive symptoms (proportion mediated = 13%-16%). CONCLUSIONS: In sum, future cohort studies and dietary interventions should focus on associations of dietary vitamin E with cognitive decline, specifically for domains of verbal memory, verbal fluency, and psychomotor speed.
Authors: K H Masaki; K G Losonczy; G Izmirlian; D J Foley; G W Ross; H Petrovitch; R Havlik; L R White Journal: Neurology Date: 2000-03-28 Impact factor: 9.910
Authors: Gerda G Fillenbaum; Maragatha N Kuchibhatla; Joseph T Hanlon; Margaret B Artz; Carl F Pieper; Kenneth E Schmader; Maurice W Dysken; Shelly L Gray Journal: Ann Pharmacother Date: 2005-10-14 Impact factor: 3.154
Authors: Martha Clare Morris; Denis A Evans; Christine C Tangney; Julia L Bienias; Robert S Wilson; Neelum T Aggarwal; Paul A Scherr Journal: Am J Clin Nutr Date: 2005-02 Impact factor: 7.045
Authors: Peter P Zandi; James C Anthony; Ara S Khachaturian; Stephanie V Stone; Deborah Gustafson; JoAnn T Tschanz; Maria C Norton; Kathleen A Welsh-Bohmer; John C S Breitner Journal: Arch Neurol Date: 2004-01
Authors: H J Wengreen; R G Munger; C D Corcoran; P Zandi; K M Hayden; M Fotuhi; I Skoog; M C Norton; J Tschanz; J C S Breitner; K A Welsh-Bohmer Journal: J Nutr Health Aging Date: 2007 May-Jun Impact factor: 4.075
Authors: Ganesh M Babulal; Yakeel T Quiroz; Benedict C Albensi; Eider Arenaza-Urquijo; Arlene J Astell; Claudio Babiloni; Alex Bahar-Fuchs; Joanne Bell; Gene L Bowman; Adam M Brickman; Gaël Chételat; Carrie Ciro; Ann D Cohen; Peggye Dilworth-Anderson; Hiroko H Dodge; Simone Dreux; Steven Edland; Anna Esbensen; Lisbeth Evered; Michael Ewers; Keith N Fargo; Juan Fortea; Hector Gonzalez; Deborah R Gustafson; Elizabeth Head; James A Hendrix; Scott M Hofer; Leigh A Johnson; Roos Jutten; Kerry Kilborn; Krista L Lanctôt; Jennifer J Manly; Ralph N Martins; Michelle M Mielke; Martha Clare Morris; Melissa E Murray; Esther S Oh; Mario A Parra; Robert A Rissman; Catherine M Roe; Octavio A Santos; Nikolaos Scarmeas; Lon S Schneider; Nicole Schupf; Sietske Sikkes; Heather M Snyder; Hamid R Sohrabi; Yaakov Stern; Andre Strydom; Yi Tang; Graciela Muniz Terrera; Charlotte Teunissen; Debora Melo van Lent; Michael Weinborn; Linda Wesselman; Donna M Wilcock; Henrik Zetterberg; Sid E O'Bryant Journal: Alzheimers Dement Date: 2018-12-13 Impact factor: 21.566
Authors: Michelle M Mielke; Neelum T Aggarwal; Clara Vila-Castelar; Puja Agarwal; Eider M Arenaza-Urquijo; Benjamin Brett; Anna Brugulat-Serrat; Lyndsey E DuBose; Willem S Eikelboom; Jason Flatt; Nancy S Foldi; Sanne Franzen; Paola Gilsanz; Wei Li; Alison J McManus; Debora Melo van Lent; Sadaf Arefi Milani; C Elizabeth Shaaban; Shana D Stites; Erin Sundermann; Vidyani Suryadevara; Jean-Francoise Trani; Arlener D Turner; Jet M J Vonk; Yakeel T Quiroz; Ganesh M Babulal Journal: Alzheimers Dement Date: 2022-04-08 Impact factor: 16.655
Authors: Regina S Wright; Shari R Waldstein; Marie Fanelli Kuczmarski; Ryan T Pohlig; Constance S Gerassimakis; Beatrice Gaynor; Michele K Evans; Alan B Zonderman Journal: Public Health Nutr Date: 2016-06-03 Impact factor: 4.022
Authors: Ronald M Lazar; Virginia J Howard; Walter N Kernan; Hugo J Aparicio; Deborah A Levine; Anthony J Viera; Lori C Jordan; David L Nyenhuis; Katherine L Possin; Farzaneh A Sorond; Carole L White Journal: Stroke Date: 2021-03-15 Impact factor: 7.914
Authors: C N Black; B W J H Penninx; M Bot; A O Odegaard; M D Gross; K A Matthews; D R Jacobs Journal: Transl Psychiatry Date: 2016-02-23 Impact factor: 7.989