Shweta Dr1, Anuradha Khanna2. 1. Assistant Professor, MGMCRI , Pondicherry, India . 2. Professor, Institute of Medical Sciences , Bhu, Varanasi, India .
Abstract
INTRODUCTION: The present study was conducted in the Department of Obstetrics, Paediatrics & Biophysics IMS, BHU, Varanasi with an aim to study the role of L-arginine and oral antioxidants as a part of therapy in patients diagnosed with IUGR (Intra uterine growth restriction ) and cord serum NO and oxidative stress markers GSH and SOD in newborns following delivery of such patients. MATERIALS AND METHODS: The study included 40 pregnant patient between 30-32 weeks of gestation diagnosed with IUGR who were divided into 3 groups: Group I (treated with L-arginine N=10), Group II (treated with antioxidants N=10), Group III (without nutritional supplementation N=10) and Group IV (healthy control pregnant patients of same gestational age range N=10) were taken. Cord serum NO & oxidative stress markers (GSH & SOD) were measured following delivery of patients from those four groups. RESULTS: The cord serumNO levels (μmol/lt) showed a significant increase & SOD (U/ml) & GSH (U/lt) values were increased in newborns to mothers diagnosed with IUGR after treatment with L-arginine. Similar results were obtained for treatment with antioxidants. CONCLUSION: The reduced NO & reduced cord serum circulating levels of oxidative stress markers (GSH & SOD) activity may play an important role in the occurrence of IUGR.
RCT Entities:
INTRODUCTION: The present study was conducted in the Department of Obstetrics, Paediatrics & Biophysics IMS, BHU, Varanasi with an aim to study the role of L-arginine and oral antioxidants as a part of therapy in patients diagnosed with IUGR (Intra uterine growth restriction ) and cord serum NO and oxidative stress markers GSH and SOD in newborns following delivery of such patients. MATERIALS AND METHODS: The study included 40 pregnant patient between 30-32 weeks of gestation diagnosed with IUGR who were divided into 3 groups: Group I (treated with L-arginine N=10), Group II (treated with antioxidants N=10), Group III (without nutritional supplementation N=10) and Group IV (healthy control pregnant patients of same gestational age range N=10) were taken. Cord serum NO & oxidative stress markers (GSH & SOD) were measured following delivery of patients from those four groups. RESULTS: The cord serum NO levels (μmol/lt) showed a significant increase & SOD (U/ml) & GSH (U/lt) values were increased in newborns to mothers diagnosed with IUGR after treatment with L-arginine. Similar results were obtained for treatment with antioxidants. CONCLUSION: The reduced NO & reduced cord serum circulating levels of oxidative stress markers (GSH & SOD) activity may play an important role in the occurrence of IUGR.
Authors: Lucy C Chappell; Paul T Seed; Frank J Kelly; Annette Briley; Beverley J Hunt; D Stephen Charnock-Jones; Anthony Mallet; Lucilla Poston Journal: Am J Obstet Gynecol Date: 2002-09 Impact factor: 8.661