X M Xiao1, L P Li. 1. Department of Gynecology/Obstetrics, First Affiliated Hospital of Jinan University, Guangzhou, China.
Abstract
OBJECTIVES: [corrected] To investigate the effects of L-Arginine in treating asymmetric fetal growth restriction (FGR). METHODS: A total of 66 pregnant women whose fetuses were diagnosed with asymmetric fetal growth restriction were divided into two groups. Group 1 consisted of 36 women who were given routine therapy alone; group 2 consisted of 30 women who were givenL-Arginine and routine therapy; and the control group consisted of 30 more women with a normal pregnancy. RESULTS: Before treatment, mean maternal serum levels of NO2-/NO3- were significantly lower in groups 1 and 2 than in the control group (P<0.01). After treatment, maternal serum levels of NO2-/NO3- were considerably higher in group 2 than in group 1 (P<0.01). Mean birth weight was significantly higher in group 2 than in group 1 (P<0.05), but still lower in group 2 than in the control group (P<0.01). CONCLUSIONS: A deficiency in nitric oxide may play an important role in the development of asymmetric fetal growth restriction. L-Arginine can be used to increase maternal NO2-/NO3- levels and newborn birth weight.
RCT Entities:
OBJECTIVES: [corrected] To investigate the effects of L-Arginine in treating asymmetric fetal growth restriction (FGR). METHODS: A total of 66 pregnant women whose fetuses were diagnosed with asymmetric fetal growth restriction were divided into two groups. Group 1 consisted of 36 women who were given routine therapy alone; group 2 consisted of 30 women who were given L-Arginine and routine therapy; and the control group consisted of 30 more women with a normal pregnancy. RESULTS: Before treatment, mean maternal serum levels of NO2-/NO3- were significantly lower in groups 1 and 2 than in the control group (P<0.01). After treatment, maternal serum levels of NO2-/NO3- were considerably higher in group 2 than in group 1 (P<0.01). Mean birth weight was significantly higher in group 2 than in group 1 (P<0.05), but still lower in group 2 than in the control group (P<0.01). CONCLUSIONS:A deficiency in nitric oxide may play an important role in the development of asymmetric fetal growth restriction. L-Arginine can be used to increase maternal NO2-/NO3- levels and newborn birth weight.
Authors: Lawrence P Reynolds; Joel S Caton; Dale A Redmer; Anna T Grazul-Bilska; Kimberly A Vonnahme; Pawel P Borowicz; Justin S Luther; Jacqueline M Wallace; Guoyao Wu; Thomas E Spencer Journal: J Physiol Date: 2006-02-09 Impact factor: 5.182
Authors: Anne Marie Darling; Chloe R McDonald; Willy S Urassa; Kevin C Kain; Ramadhani S Mwiru; Wafaie W Fawzi Journal: Am J Epidemiol Date: 2017-09-01 Impact factor: 4.897
Authors: Junjun Wang; Zhenlong Wu; Defa Li; Ning Li; Scott V Dindot; M Carey Satterfield; Fuller W Bazer; Guoyao Wu Journal: Antioxid Redox Signal Date: 2012-01-13 Impact factor: 8.401
Authors: Guoyao Wu; Fuller W Bazer; Teresa A Davis; Sung Woo Kim; Peng Li; J Marc Rhoads; M Carey Satterfield; Stephen B Smith; Thomas E Spencer; Yulong Yin Journal: Amino Acids Date: 2008-11-23 Impact factor: 3.520