Literature DB >> 25478365

Dexmedetomidine in current anaesthesia practice- a review.

Shagufta Naaz1, Erum Ozair2.   

Abstract

Dexmedetomidine is an alpha 2 adrenergic receptor agonist, even ten times more selective than clonidine. It is a very versatile drug in anaesthesia practice, finding place in increasing number of clinical scenarios and is no more limited to intensive care unit (ICU) sedation. It is analgesic, has anaesthetic sparing effect, sympatholytic property, useful in other procedural sedation and also has cardiovascular stabilizing property. It reduces delirium and preserves respiratory function which adds benefits to its uses. The aim of this review is to make awareness of its role in present anaesthesia and discuss its limitations at the same time.

Entities:  

Keywords:  Alpha 2 adrenergic agonist; Anaesthesia; Dexmedetomidine; Intensive care unit

Year:  2014        PMID: 25478365      PMCID: PMC4253183          DOI: 10.7860/JCDR/2014/9624.4946

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  48 in total

Review 1.  alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role.

Authors:  Z P Khan; C N Ferguson; R M Jones
Journal:  Anaesthesia       Date:  1999-02       Impact factor: 6.955

Review 2.  Dexmedetomidine: antiarrhythmic effects in the pediatric cardiac patient.

Authors:  Joseph D Tobias; Constantinos Chrysostomou
Journal:  Pediatr Cardiol       Date:  2013-02-24       Impact factor: 1.655

3.  Intramuscular dexmedetomidine sedation for pediatric MRI and CT.

Authors:  Keira P Mason; Nina B Lubisch; Fay Robinson; Rudolph Roskos
Journal:  AJR Am J Roentgenol       Date:  2011-09       Impact factor: 3.959

4.  Anesthesia for a patient with morbid obesity using dexmedetomidine without narcotics.

Authors:  Roger E Hofer; Juraj Sprung; Michael G Sarr; Denise J Wedel
Journal:  Can J Anaesth       Date:  2005-02       Impact factor: 5.063

5.  Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial.

Authors:  Pratik P Pandharipande; Brenda T Pun; Daniel L Herr; Mervyn Maze; Timothy D Girard; Russell R Miller; Ayumi K Shintani; Jennifer L Thompson; James C Jackson; Stephen A Deppen; Renee A Stiles; Robert S Dittus; Gordon R Bernard; E Wesley Ely
Journal:  JAMA       Date:  2007-12-12       Impact factor: 56.272

6.  High dose dexmedetomidine as the sole sedative for pediatric MRI.

Authors:  Keira P Mason; David Zurakowski; Steven E Zgleszewski; Caroline D Robson; Maureen Carrier; Paul R Hickey; James A Dinardo
Journal:  Paediatr Anaesth       Date:  2008-03-18       Impact factor: 2.556

7.  Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor.

Authors:  Tatsushi Yoshitomi; Atsushi Kohjitani; Shigeru Maeda; Hitoshi Higuchi; Masahiko Shimada; Takuya Miyawaki
Journal:  Anesth Analg       Date:  2008-07       Impact factor: 5.108

8.  Dexmedetomidine for awake carotid endarterectomy: efficacy, hemodynamic profile, and side effects.

Authors:  Alex Y Bekker; John Basile; Mark Gold; Thomas Riles; Mark Adelman; Germaine Cuff; Jomol P Mathew; Judith D Goldberg
Journal:  J Neurosurg Anesthesiol       Date:  2004-04       Impact factor: 3.956

9.  Dexmedetomidine versus propofol for sedation in patients undergoing vitreoretinal surgery under sub-Tenon's anesthesia.

Authors:  Ashraf Ghali; Abdul Kader Mahfouz; Tapio Ihanamäki; Ashraf M El Btarny
Journal:  Saudi J Anaesth       Date:  2011-01

Review 10.  Current role of dexmedetomidine in clinical anesthesia and intensive care.

Authors:  Manpreet Kaur; P M Singh
Journal:  Anesth Essays Res       Date:  2011 Jul-Dec
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  41 in total

1.  Dexmedetomidine-assisted drug interviews: an observation in psychiatric setting.

Authors:  Devalina Goswami; Harshit Garg; Hamsenandinie Carounagarane; Koushik Sinha Deb
Journal:  BMJ Case Rep       Date:  2018-12-14

Review 2.  Spinal α2 -adrenoceptors and neuropathic pain modulation; therapeutic target.

Authors:  Zahra Bahari; Gholam Hossein Meftahi
Journal:  Br J Pharmacol       Date:  2019-03-06       Impact factor: 8.739

3.  Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes.

Authors:  Mengyao Ding; Ying Chen; Hengfei Luan; Xiaobao Zhang; Zhibin Zhao; Yong Wu
Journal:  Exp Ther Med       Date:  2019-07-18       Impact factor: 2.447

4.  Evaluating sedative effects of dexmedetomidine and morphine in the patients with opioid use disorder undergoing cataract surgery.

Authors:  Dariush Moradi Farsani; Keyvan Ghadimi; Raana Abrishamkar; Kamran Montazeri; Alireza Peyman
Journal:  Am J Clin Exp Immunol       Date:  2021-02-15

5.  Implications of Electronic Cigarettes on the Safe Administration of Sedation and General Anesthesia in the Outpatient Dental Setting.

Authors:  Zachary A Heller; Edward C Adlesic Ms; Jason E Portnof Dmd
Journal:  Anesth Prog       Date:  2022-06-01

6.  A Comparative Study Evaluating the Efficacy of Lignocaine and Dexmedetomidine with Lignocaine and Adrenaline in Third Molar Surgery.

Authors:  Thomson Mariadasan Dcruz; Charmiben Patel; Abhijeet Masih; Izaz Shaik
Journal:  J Maxillofac Oral Surg       Date:  2020-11-09

7.  Intraperitoneal Alfaxalone and Alfaxalone-Dexmedetomidine Anesthesia in Sprague-Dawley Rats (Rattus norvegicus).

Authors:  Sylvia E West; Jonathan C Lee; Tinika N Johns; Elizabeth A Nunamaker
Journal:  J Am Assoc Lab Anim Sci       Date:  2020-08-05       Impact factor: 1.232

8.  Comparison of Efficacy of Bupivacaine with Dexmedetomidine Versus Bupivacaine Alone for Transversus Abdominis Plane Block for Post-operative Analgesia in Patients Undergoing Elective Caesarean Section.

Authors:  A Ramya Parameswari; Prabha Udayakumar
Journal:  J Obstet Gynaecol India       Date:  2017-04-26

9.  Effects of dexmedetomidine on blood coagulation: an in vitro study using rotational thromboelastometry.

Authors:  Hyun-Jung Shin; Gihong Boo; Hyo-Seok Na
Journal:  J Anesth       Date:  2021-07-15       Impact factor: 2.078

10.  The Choice of Anesthetic Agents for Endoscopic Sinus Surgery: Can Sinus Surgeons Be Involved?

Authors:  Yong Gi Jung
Journal:  Clin Exp Otorhinolaryngol       Date:  2021-04-30       Impact factor: 3.372

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