Literature DB >> 25475061

Choreography of AMPK activation.

Christopher G Langendorf1, Bruce E Kemp1.   

Abstract

A recent study published in Cell Research by Li and colleagues reports a detailed biophysical and structural study of AMPK's intra-molecular interactions during activation. By employing subunit tagging and proximity analysis with the aid of AlphaScreen instrumentation, Li et al. add to our understanding of the choreography of activation of AMPK by both nucleotides and phosphorylation.

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Year:  2014        PMID： 25475061      PMCID： PMC4650591          DOI： 10.1038/cr.2014.163

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  11 in total

1.  Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1.

Authors:  Gabriele A Amodeo; Michael J Rudolph; Liang Tong
Journal:  Nature       Date:  2007-09-12       Impact factor: 49.962

2.  Structural insight into the autoinhibition mechanism of AMP-activated protein kinase.

Authors:  Lei Chen; Zhi-Hao Jiao; Li-Sha Zheng; Yuan-Yuan Zhang; Shu-Tao Xie; Zhi-Xin Wang; Jia-Wei Wu
Journal:  Nature       Date:  2009-05-27       Impact factor: 49.962

3.  Conserved regulatory elements in AMPK.

Authors:  Lei Chen; Feng-Jiao Xin; Jue Wang; Jicheng Hu; Yuan-Yuan Zhang; Shuo Wan; Lu-Sha Cao; Chang Lu; Peng Li; S Frank Yan; Dietbert Neumann; Uwe Schlattner; Bin Xia; Zhi-Xin Wang; Jia-Wei Wu
Journal:  Nature       Date:  2013-06-13       Impact factor: 49.962

4.  Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

Authors:  Matthew F Calabrese; Francis Rajamohan; Melissa S Harris; Nicole L Caspers; Rachelle Magyar; Jane M Withka; Hong Wang; Kris A Borzilleri; Parag V Sahasrabudhe; Lise R Hoth; Kieran F Geoghegan; Seungil Han; Janice Brown; Timothy A Subashi; Allan R Reyes; Richard K Frisbie; Jessica Ward; Russell A Miller; James A Landro; Allyn T Londregan; Philip A Carpino; Shawn Cabral; Aaron C Smith; Edward L Conn; Kimberly O Cameron; Xiayang Qiu; Ravi G Kurumbail
Journal:  Structure       Date:  2014-07-24       Impact factor: 5.006

5.  AMP-activated protein kinase undergoes nucleotide-dependent conformational changes.

Authors:  Lei Chen; Jue Wang; Yuan-Yuan Zhang; S Frank Yan; Dietbert Neumann; Uwe Schlattner; Zhi-Xin Wang; Jia-Wei Wu
Journal:  Nat Struct Mol Biol       Date:  2012-06-03       Impact factor: 15.369

6.  AMPK beta subunit targets metabolic stress sensing to glycogen.

Authors:  Galina Polekhina; Abhilasha Gupta; Belinda J Michell; Bryce van Denderen; Sid Murthy; Susanne C Feil; Ian G Jennings; Duncan J Campbell; Lee A Witters; Michael W Parker; Bruce E Kemp; David Stapleton
Journal:  Curr Biol       Date:  2003-05-13       Impact factor: 10.834

7.  Structural properties of AMP-activated protein kinase: dimerization, molecular shape, and changes upon ligand binding.

Authors:  Uwe Riek; Roland Scholz; Peter Konarev; Arne Rufer; Marianne Suter; Alexis Nazabal; Philippe Ringler; Mohamed Chami; Shirley A Müller; Dietbert Neumann; Michael Forstner; Michael Hennig; Renato Zenobi; Andreas Engel; Dmitri Svergun; Uwe Schlattner; Theo Wallimann
Journal:  J Biol Chem       Date:  2008-03-27       Impact factor: 5.157

8.  Structure of mammalian AMPK and its regulation by ADP.

Authors:  Bing Xiao; Matthew J Sanders; Elizabeth Underwood; Richard Heath; Faith V Mayer; David Carmena; Chun Jing; Philip A Walker; John F Eccleston; Lesley F Haire; Peter Saiu; Steven A Howell; Rein Aasland; Stephen R Martin; David Carling; Steven J Gamblin
Journal:  Nature       Date:  2011-03-13       Impact factor: 49.962

9.  Structural basis of AMPK regulation by small molecule activators.

Authors:  Bing Xiao; Matthew J Sanders; David Carmena; Nicola J Bright; Lesley F Haire; Elizabeth Underwood; Bhakti R Patel; Richard B Heath; Philip A Walker; Stefan Hallen; Fabrizio Giordanetto; Stephen R Martin; David Carling; Steven J Gamblin
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

10.  Structural basis of AMPK regulation by adenine nucleotides and glycogen.

Authors:  Xiaodan Li; Lili Wang; X Edward Zhou; Jiyuan Ke; Parker W de Waal; Xin Gu; M H Eileen Tan; Dongye Wang; Donghai Wu; H Eric Xu; Karsten Melcher
Journal:  Cell Res       Date:  2014-11-21       Impact factor: 25.617
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  23 in total

1.  Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK).

Authors:  Xin Gu; Michael D Bridges; Yan Yan; Parker W de Waal; X Edward Zhou; Kelly M Suino-Powell; H Eric Xu; Wayne L Hubbell; Karsten Melcher
Journal:  J Biol Chem       Date:  2018-09-11       Impact factor: 5.157

2.  Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator.

Authors:  Ashley J Ovens; Yi Sing Gee; Naomi X Y Ling; Dingyi Yu; Justin P Hardee; Jin D Chung; Kevin R W Ngoei; Nicholas J Waters; Nolan J Hoffman; John W Scott; Kim Loh; Katrin Spengler; Regine Heller; Michael W Parker; Gordon S Lynch; Fei Huang; Sandra Galic; Bruce E Kemp; Jonathan B Baell; Jonathan S Oakhill; Christopher G Langendorf
Journal:  Biochem J       Date:  2022-06-17       Impact factor: 3.766

Review 3.  AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs.

Authors:  D Grahame Hardie; Bethany E Schaffer; Anne Brunet
Journal:  Trends Cell Biol       Date:  2015-11-23       Impact factor: 20.808

Review 4.  AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.

Authors:  Ian P Salt; D Grahame Hardie
Journal:  Circ Res       Date:  2017-05-26       Impact factor: 17.367

5.  β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase.

Authors:  Nada Ali; Naomi Ling; Srinath Krishnamurthy; Jonathan S Oakhill; John W Scott; David I Stapleton; Bruce E Kemp; Ganesh Srinivasan Anand; Paul R Gooley
Journal:  Sci Rep       Date:  2016-12-21       Impact factor: 4.379

6.  Identification of Direct Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Structure-Based Virtual Screening and Molecular Docking Approach.

Authors:  Tonghui Huang; Jie Sun; Shanshan Zhou; Jian Gao; Yi Liu
Journal:  Int J Mol Sci       Date:  2017-06-30       Impact factor: 5.923

7.  Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib.

Authors:  Fiona A Ross; Simon A Hawley; F Romana Auciello; Graeme J Gowans; Abdelmadjid Atrih; Douglas J Lamont; D Grahame Hardie
Journal:  Cell Chem Biol       Date:  2017-06-15       Impact factor: 8.116

8.  Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.

Authors:  Christopher G Langendorf; Kevin R W Ngoei; John W Scott; Naomi X Y Ling; Sam M A Issa; Michael A Gorman; Michael W Parker; Kei Sakamoto; Jonathan S Oakhill; Bruce E Kemp
Journal:  Nat Commun       Date:  2016-03-08       Impact factor: 14.919

9.  Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.

Authors:  Chen-Song Zhang; Simon A Hawley; Yue Zong; Mengqi Li; Zhichao Wang; Alexander Gray; Teng Ma; Jiwen Cui; Jin-Wei Feng; Mingjiang Zhu; Yu-Qing Wu; Terytty Yang Li; Zhiyun Ye; Shu-Yong Lin; Huiyong Yin; Hai-Long Piao; D Grahame Hardie; Sheng-Cai Lin
Journal:  Nature       Date:  2017-07-19       Impact factor: 49.962

Review 10.  Keeping the home fires burning: AMP-activated protein kinase.

Authors:  D Grahame Hardie
Journal:  J R Soc Interface       Date:  2018-01       Impact factor: 4.118
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