| Literature DB >> 22659875 |
Lei Chen1, Jue Wang, Yuan-Yuan Zhang, S Frank Yan, Dietbert Neumann, Uwe Schlattner, Zhi-Xin Wang, Jia-Wei Wu.
Abstract
The energy sensor AMP-activated protein kinase (AMPK) is a heterotrimeric complex that is allosterically activated by AMP binding to the γ subunit. Cocrystal structures of the mammalian AMPK core reveal occlusion of nucleotide-binding site 3 of the γ subunit in the presence of ATP. However, site 3 is occupied in the presence of AMP. Mutagenesis studies indicate that sites 3 and 4 are important for AMPK allosteric activation.Entities:
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Year: 2012 PMID： 22659875 DOI： 10.1038/nsmb.2319
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369