Literature DB >> 25471208

Krebs cycle metabolon formation: metabolite concentration gradient enhanced compartmentation of sequential enzymes.

Fei Wu1, Lindsey N Pelster, Shelley D Minteer.   

Abstract

Dynamics of metabolon formation in mitochondria was probed by studying diffusional motion of two sequential Krebs cycle enzymes in a microfluidic channel. Enhanced directional co-diffusion of both enzymes against a substrate concentration gradient was observed in the presence of intermediate generation. This reveals a metabolite directed compartmentation of metabolic pathways.

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Year:  2015        PMID： 25471208     DOI： 10.1039/c4cc08702j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  12 in total

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Authors:  Youjun Zhang; Katherine F M Beard; Corné Swart; Susan Bergmann; Ina Krahnert; Zoran Nikoloski; Alexander Graf; R George Ratcliffe; Lee J Sweetlove; Alisdair R Fernie; Toshihiro Obata
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Journal:  Nat Commun       Date:  2018-05-30       Impact factor: 14.919

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Review 9.  Enzymatic complexes across scales.

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Review 10.  Metabolons, enzyme-enzyme assemblies that mediate substrate channeling, and their roles in plant metabolism.

Authors:  Youjun Zhang; Alisdair R Fernie
Journal:  Plant Commun       Date:  2020-06-05
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