| Literature DB >> 25469288 |
Fei Sha1, Shanshan Zhuang2, Li Zhou3, Liqun Zhang4, Yuxian Yang5, Shengqi Zhang5, Yi Jiang5, Guodong Qiu1, Chen Chen1, Jieting Zheng1, Shuyao Zhang1.
Abstract
This study was conducted to investigate the biomarkers that appear to be correlated with cancer-related fatigue (CRF) and the adverse reactions (ADRs) to chemotherapy. A total of 100 lung cancer patients were selected and CRF prior to and following chemotherapy was evaluated. The plasma levels of tumor necrosis factor (TNF)-α and interleukin (IL)-1 and the level of 17-hydroxycorticosteroid (17-OHCS) in the urine were analyzed and correlated with CRF and the ADRs associated with chemotherapy. The incidence of CRF was found to be 88.0% and ADRs following chemotherapy occurred in 15.0% of the patients. An increase in the TNF-α and IL-1 levels was detected in patients with CRF. The level of 17-OHCS in the urine was found to be elevated in cases that experienced ADRs following chemotherapy. In conclusion, CRF is closely correlated with increased plasma levels of TNF-α and IL-1. Furthermore, an abnormally elevated 17-OHCS level in the urine may be an important indicator predicting ADR development following chemotherapy.Entities:
Keywords: 17-hydroxycorticosteroid; adverse reactions to chemotherapy; cancer-related fatigue; interleukin 1; lung cancer; tumor necrosis factor-α
Year: 2014 PMID： 25469288 PMCID： PMC4251268 DOI： 10.3892/mco.2014.439
Source DB: PubMed Journal: Mol Clin Oncol ISSN： 2049-9450