Literature DB >> 25469282

Prognostic value of serum α-fetoprotein in ovarian yolk sac tumors: A systematic review and meta-analysis.

Yang-Long Guo1, Ying-Li Zhang1, Jian-Qing Zhu1.   

Abstract

This study was conducted to determine the prognostic value of serum α-fetoprotein (AFP) levels in patients with ovarian yolk sac tumor (OYST). We performed a systematic review and meta-analysis to assess the associations between serum AFP level and prognosis in OYST. A total of 12 quantitative studies met the inclusion criteria. Preoperative AFP was not found to be associated with overall survival (OS) [odds ratio (OR)=0.84, 95% confidence interval (CI): 0.43-1.62] in OYST. However, a high postoperative AFP level was associated with worse OS (OR=0.16, 95% CI: 0.05-0.48) and relapse-free survival (RFS) (OR=0.18, 95% CI: 0.08-0.43) compared to a low postoperative AFP level in patients with OYST. In addition, a postoperative AFP level of >1,000 ng/ml was associated with a decrease in OS (OR=0.16, 95% CI: 0.05-0.50) and RFS (OR=0.21, 95% CI: 0.08-0.57). In conclusion, the postoperative, but not the preoperative, AFP level was found to be a prognostic factor in patients with OYST. In particular, a postoperative AFP level of >1,000 ng/ml was an indicator of poor prognosis in patients with OYST.

Entities:  

Keywords:  ovarian yolk sac tumor; prognosis; α-fetoprotein

Year:  2014        PMID： 25469282      PMCID： PMC4251123          DOI： 10.3892/mco.2014.417

Source DB:  PubMed          Journal:  Mol Clin Oncol        ISSN： 2049-9450


  26 in total

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4.  Treatment of nondysgerminomatous ovarian germ cell tumors: an analysis of 69 cases.

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Journal:  Cancer       Date:  1991-01-01       Impact factor: 6.860

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Authors:  Penny F Whiting; Anne W S Rutjes; Marie E Westwood; Susan Mallett; Jonathan J Deeks; Johannes B Reitsma; Mariska M G Leeflang; Jonathan A C Sterne; Patrick M M Bossuyt
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  7 in total

1.  Primary Nasopharngeal Yolk Sac Tumor: A Case Report.

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Authors:  Fang Zhu; Lixia Wang; Xiaoli Zhai
Journal:  Int J Clin Exp Pathol       Date:  2020-11-01

3.  Primary yolk sac tumor of the gluteus: a case report and literature review.

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4.  Yolk sac tumor in the abdominal wall of an 18-month-old girl: a case report.

Authors:  Machiel van den Akker; Dirk Vervloessem; An Huybrechs; Sabine Declercq; Jutte van der Werff Ten Bosch
Journal:  J Med Case Rep       Date:  2017-02-20

5.  Primary posterior mediastinal germ cell tumor in a child.

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6.  Yolk sac tumor presenting as a colonic mass in a post-menopausal woman: A case report.

Authors:  R Short; M Greenwade; A Bonebrake
Journal:  Gynecol Oncol Rep       Date:  2022-07-02

7.  Relapsed and refractory yolk sac tumor of the peritoneum (mesentery): A case report and literature review.

Authors:  Xue Zhou; Lanbo Zhao; Xue Feng; Zhenni Pan; Yadi Bin; Siyi Zhang; Min Li; Miao Guo; Huilian Hou; Qiling Li
Journal:  Front Oncol       Date:  2022-08-09       Impact factor: 5.738
  7 in total

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