Literature DB >> 25467948

A bioassay using intestinal organoids to measure CFTR modulators in human plasma.

R Dekkers1, L A W Vijftigschild1, A M Vonk1, E Kruisselbrink1, K M de Winter-de Groot2, H M Janssens3, C K van der Ent2, J M Beekman4.   

Abstract

Treatment efficacies of drugs depend on patient-specific pharmacokinetic and pharmacodynamic properties. Here, we developed an assay to measure functional levels of the CFTR potentiator VX-770 in human plasma and observed that VX-770 in plasma from different donors induced variable CFTR function in intestinal organoids. This assay can help to understand variability in treatment response to CFTR potentiators by functionally modeling individual pharmacokinetics.
Copyright © 2014. Published by Elsevier B.V.

Entities:  

Keywords:  CFTR; Intestinal organoids; Personalized medicine; Pharmacokinetics; VX-770

Mesh：

Substances：

Year:  2014        PMID： 25467948     DOI： 10.1016/j.jcf.2014.10.007

Source DB:  PubMed          Journal:  J Cyst Fibros        ISSN： 1569-1993            Impact factor:   5.482


  18 in total

1.  Detection of CFTR function and modulation in primary human nasal cell spheroids.

Authors:  John J Brewington; Erin T Filbrandt; F J LaRosa; Alicia J Ostmann; Lauren M Strecker; Rhonda D Szczesniak; John P Clancy
Journal:  J Cyst Fibros       Date:  2017-07-13       Impact factor: 5.482

2.  Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25-28 March 2015.

Authors:  Alan S Verkman; Aleksander Edelman; Margarida Amaral; Marcus A Mall; Jeffrey M Beekman; Torsten Meiners; Luis J V Galietta; Christine E Bear
Journal:  J Cyst Fibros       Date:  2015-10-21       Impact factor: 5.482

3.  Nasospheroids permit measurements of CFTR-dependent fluid transport.

Authors:  Jennifer S Guimbellot; Justin M Leach; Imron G Chaudhry; Nancy L Quinney; Susan E Boyles; Michael Chua; Inmaculada Aban; Ilona Jaspers; Martina Gentzsch
Journal:  JCI Insight       Date:  2017-11-16

4.  Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients.

Authors:  Sylvia F Boj; Annelotte M Vonk; Marvin Statia; Jinyi Su; Robert R G Vries; Jeffrey M Beekman; Hans Clevers
Journal:  J Vis Exp       Date:  2017-02-11       Impact factor: 1.355

5.  Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study.

Authors:  John J Brewington; Erin T Filbrandt; Francis J LaRosa; Jessica D Moncivaiz; Alicia J Ostmann; Lauren M Strecker; John P Clancy
Journal:  J Vis Exp       Date:  2018-04-11       Impact factor: 1.355

Review 6.  New Therapeutic Approaches to Modulate and Correct Cystic Fibrosis Transmembrane Conductance Regulator.

Authors:  Thida Ong; Bonnie W Ramsey
Journal:  Pediatr Clin North Am       Date:  2016-08       Impact factor: 3.278

Review 7.  Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals.

Authors:  Sathidpak Nantasanti; Alain de Bruin; Jan Rothuizen; Louis C Penning; Baukje A Schotanus
Journal:  Stem Cells Transl Med       Date:  2016-01-21       Impact factor: 6.940

Review 8.  Toward inclusive therapy with CFTR modulators: Progress and challenges.

Authors:  Jennifer Guimbellot; Jyoti Sharma; Steven M Rowe
Journal:  Pediatr Pulmonol       Date:  2017-09-07

Review 9.  CFTR modulator theratyping: Current status, gaps and future directions.

Authors:  John Paul Clancy; Calvin U Cotton; Scott H Donaldson; George M Solomon; Donald R VanDevanter; Michael P Boyle; Martina Gentzsch; Jerry A Nick; Beate Illek; John C Wallenburg; Eric J Sorscher; Margarida D Amaral; Jeffrey M Beekman; Anjaparavanda P Naren; Robert J Bridges; Philip J Thomas; Garry Cutting; Steven Rowe; Anthony G Durmowicz; Martin Mense; Kris D Boeck; William Skach; Christopher Penland; Elizabeth Joseloff; Hermann Bihler; John Mahoney; Drucy Borowitz; Katherine L Tuggle
Journal:  J Cyst Fibros       Date:  2018-06-20       Impact factor: 5.482

10.  Brushed nasal epithelial cells are a surrogate for bronchial epithelial CFTR studies.

Authors:  John J Brewington; Erin T Filbrandt; F J LaRosa; Jessica D Moncivaiz; Alicia J Ostmann; Lauren M Strecker; John P Clancy
Journal:  JCI Insight       Date:  2018-07-12
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