Priya Bhide1, Merve Dilgil2, Anil Gudi2, Amit Shah2, Charity Akwaa2, Roy Homburg2. 1. Homerton Fertility Centre, Homerton University Hospital, London, United Kingdom. Electronic address: priya.bhide@homerton.nhs.uk. 2. Homerton Fertility Centre, Homerton University Hospital, London, United Kingdom.
Abstract
OBJECTIVE: To ascertain if subfertile women with polycystic ovary syndrome (PCOS) secrete more antimüllerian hormone (AMH) per antral follicle than control women. DESIGN: Observational cross-sectional study. SETTING: Fertility clinic. PATIENT(S): A total of 438 women attending the fertility clinic over a period of 13 months from September 2012 to September 2013. INTERVENTION(S): Serum concentrations of AMH and the total antral follicle count (AFC) were obtained from women attending the fertility clinic. The ratio of AMH/AFC for each subject was calculated. Women were categorized into three groups: PCOS, polycystic ovarian morphology (PCOM), and control. PCOS and PCOM were defined based on the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine Rotterdam consensus criteria. MAIN OUTCOME MEASURE(S): The ratio of AMH/AFC for each subject in the three groups: PCOS, PCOM, and control. RESULT(S): The median AMH/AFC ratios in the PCOS, PCOM, and control groups were 1.92, 1.13, and 1.00, respectively. The AMH/AFC ratio was significantly higher in the PCOS group compared with the PCOM and control groups (F[2,152] = 21.82). Women in the three groups were not statistically different regarding age, body mass index, earlier ovarian surgery, and smoking status. CONCLUSION(S): Subfertile women with PCOS secrete significantly more AMH per antral follicle than women with PCOM only and control women.
OBJECTIVE: To ascertain if subfertile women with polycystic ovary syndrome (PCOS) secrete more antimüllerian hormone (AMH) per antral follicle than control women. DESIGN: Observational cross-sectional study. SETTING: Fertility clinic. PATIENT(S): A total of 438 women attending the fertility clinic over a period of 13 months from September 2012 to September 2013. INTERVENTION(S): Serum concentrations of AMH and the total antral follicle count (AFC) were obtained from women attending the fertility clinic. The ratio of AMH/AFC for each subject was calculated. Women were categorized into three groups: PCOS, polycystic ovarian morphology (PCOM), and control. PCOS and PCOM were defined based on the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine Rotterdam consensus criteria. MAIN OUTCOME MEASURE(S): The ratio of AMH/AFC for each subject in the three groups: PCOS, PCOM, and control. RESULT(S): The median AMH/AFC ratios in the PCOS, PCOM, and control groups were 1.92, 1.13, and 1.00, respectively. The AMH/AFC ratio was significantly higher in the PCOS group compared with the PCOM and control groups (F[2,152] = 21.82). Women in the three groups were not statistically different regarding age, body mass index, earlier ovarian surgery, and smoking status. CONCLUSION(S): Subfertile women with PCOS secrete significantly more AMH per antral follicle than women with PCOM only and control women.
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