Alexandra J White1, Dale P Sandler2, Aimee A D'Aloisio3, Frank Stanczyk4, Kristina W Whitworth5, Donna D Baird2, Hazel B Nichols6. 1. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. Electronic address: alexandra.white@nih.gov. 2. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. 3. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; Social and Scientific Systems, Inc., Durham, North Carolina. 4. Department of Obstetrics and Gynecology and Department of Preventative Medicine, University of Southern California Keck School of Medicine, Los Angeles, California. 5. Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health at Houston, San Antonio Regional Campus, San Antonio, Texas; Southwest Center for Occupational and Environmental Health, University of Texas School of Public Health at Houston, Houston, Texas. 6. Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina.
Abstract
OBJECTIVE: To evaluate exposure to tobacco, marijuana, and indoor heating/cooking sources in relation to antimüllerian hormone (AMH) levels. DESIGN: Cross-sectional analysis in a sample of premenopausal women (n = 913) enrolled in the Sister Study cohort (n = 50,884). SETTING: Not applicable. PATIENT(S): Women, ages 35-54 years at time of enrollment, with an archived serum sample and at least one intact ovary and classified as premenopausal. INTERVENTION(S): Not applicable. MAIN OUTCOME MEASURE(S): Serum AMH (ng/mL) levels ascertained by ultrasensitive ELISA assay. RESULT(S): Lower AMH levels were associated with sources of indoor heating, including burning wood (-36.0%; 95% confidence interval [CI], -55.7%, -7.8%) or artificial fire logs (-45.8%; 95% CI, -67.2%, -10.4%) at least 10 times/year in a residential indoor stove/fireplace. Lower AMH levels were also observed in women who were current smokers of ≥20 cigarettes/day relative to nonsmokers (-56.2%; 95% CI, -80.3%, -2.8%) and in women with 10+ years of adult environmental tobacco smoke (ETS) exposure (-31.3%; 95% CI, -51.3%, -3.1%), but no associations were observed for marijuana use. CONCLUSION(S): We confirmed previously reported findings of lower AMH levels in current heavy smokers and also found associations for long-term ETS exposure and indoor burning of wood or artificial fire logs. These findings suggest that combustion by-products from common exposures can have toxic effects on the human ovary. Published by Elsevier Inc.
OBJECTIVE: To evaluate exposure to tobacco, marijuana, and indoor heating/cooking sources in relation to antimüllerian hormone (AMH) levels. DESIGN: Cross-sectional analysis in a sample of premenopausal women (n = 913) enrolled in the Sister Study cohort (n = 50,884). SETTING: Not applicable. PATIENT(S): Women, ages 35-54 years at time of enrollment, with an archived serum sample and at least one intact ovary and classified as premenopausal. INTERVENTION(S): Not applicable. MAIN OUTCOME MEASURE(S): Serum AMH (ng/mL) levels ascertained by ultrasensitive ELISA assay. RESULT(S): Lower AMH levels were associated with sources of indoor heating, including burning wood (-36.0%; 95% confidence interval [CI], -55.7%, -7.8%) or artificial fire logs (-45.8%; 95% CI, -67.2%, -10.4%) at least 10 times/year in a residential indoor stove/fireplace. Lower AMH levels were also observed in women who were current smokers of ≥20 cigarettes/day relative to nonsmokers (-56.2%; 95% CI, -80.3%, -2.8%) and in women with 10+ years of adult environmental tobacco smoke (ETS) exposure (-31.3%; 95% CI, -51.3%, -3.1%), but no associations were observed for marijuana use. CONCLUSION(S): We confirmed previously reported findings of lower AMH levels in current heavy smokers and also found associations for long-term ETS exposure and indoor burning of wood or artificial fire logs. These findings suggest that combustion by-products from common exposures can have toxic effects on the human ovary. Published by Elsevier Inc.
Entities:
Keywords:
Anti-Müllerian Hormone; Tobacco; breast cancer; environmental tobacco smoke; indoor air pollution
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