OBJECTIVE: To evaluate whether an early postnatal infection poses a long-term risk for neuropsychological impairment to neonates born very prematurely. STUDY DESIGN: Adolescents born very preterm (n = 42, 11.6-16.2 years, mean = 13.9; 15 girls; 19 with and 23 without an early postnatal human cytomegalovirus [CMV] infection) and typically developing, term born controls (n = 24, 11.3-16.6 years, mean = 13.6; 12 girls) were neuropsychologically assessed with the German version of the Wechsler Intelligence Scale and the Developmental Test for Visual Perception. RESULTS: As expected, the full cohort of adolescents born preterm had significantly lower scores than term born controls on IQ (preterm: mean [SD] = 98.43 [14.83], control: 110.00 [8.10], P = .015) and on visuoperceptive abilities (95.64 [12.87] vs 106.24 [9.95], P = .016). Furthermore, adolescents born preterm with early postnatal CMV infection scored significantly lower than those without this infection regarding overall cognitive abilities (92.67 [14.71] vs 102.75 [13.67], P = .030), but not visuoperceptive abilities (91.22 [10.88] vs 98.96 [13.45], P > .05). CONCLUSIONS: In our small but well-characterized group, our results provide evidence for adverse effects of early postnatal CMV infection on overall cognitive functions in adolescents born preterm. If confirmed, these results support the implementation of preventive measures.
OBJECTIVE: To evaluate whether an early postnatal infection poses a long-term risk for neuropsychological impairment to neonates born very prematurely. STUDY DESIGN: Adolescents born very preterm (n = 42, 11.6-16.2 years, mean = 13.9; 15 girls; 19 with and 23 without an early postnatal human cytomegalovirus [CMV] infection) and typically developing, term born controls (n = 24, 11.3-16.6 years, mean = 13.6; 12 girls) were neuropsychologically assessed with the German version of the Wechsler Intelligence Scale and the Developmental Test for Visual Perception. RESULTS: As expected, the full cohort of adolescents born preterm had significantly lower scores than term born controls on IQ (preterm: mean [SD] = 98.43 [14.83], control: 110.00 [8.10], P = .015) and on visuoperceptive abilities (95.64 [12.87] vs 106.24 [9.95], P = .016). Furthermore, adolescents born preterm with early postnatal CMV infection scored significantly lower than those without this infection regarding overall cognitive abilities (92.67 [14.71] vs 102.75 [13.67], P = .030), but not visuoperceptive abilities (91.22 [10.88] vs 98.96 [13.45], P > .05). CONCLUSIONS: In our small but well-characterized group, our results provide evidence for adverse effects of early postnatal CMV infection on overall cognitive functions in adolescents born preterm. If confirmed, these results support the implementation of preventive measures.
Authors: Kristin E D Weimer; Matthew S Kelly; Sallie R Permar; Reese H Clark; Rachel G Greenberg Journal: JAMA Pediatr Date: 2020-02-01 Impact factor: 16.193
Authors: Haixia Zheng; Maurizio Bergamino; Bart N Ford; Rayus Kuplicki; Fang-Cheng Yeh; Jerzy Bodurka; Kaiping Burrows; Peter W Hunt; T Kent Teague; Michael R Irwin; Robert H Yolken; Martin P Paulus; Jonathan Savitz Journal: Neuropsychopharmacology Date: 2021-01-26 Impact factor: 7.853
Authors: Megan L Lloyd; Nurul Hod; Jothsna Jayaraman; Elizabeth A Marchant; Lukas Christen; Peter Chiang; Peter Hartmann; Geoffrey R Shellam; Karen Simmer Journal: PLoS One Date: 2016-08-18 Impact factor: 3.240