Kazumasa Yamagishi1, Ai Ikeda2, Yuri Moriyama3, Choy-Lye Chei4, Hiroyuki Noda3, Mitsumasa Umesawa5, Renzhe Cui3, Masanori Nagao6, Akihiko Kitamura7, Yorihiro Yamamoto8, Takashi Asada9, Hiroyasu Iso3. 1. Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan. Electronic address: yamagishi.kazumas.ge@u.tsukuba.ac.jp. 2. Department of Public Health, Juntendo University, Tokyo, Japan. 3. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan. 4. Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Health Services and Systems Research, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore. 5. Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan; Department of Public Health, Dokkyo Medical University, Mibu, Japan. 6. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan; Department of Public Health, Dokkyo Medical University, Mibu, Japan. 7. Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan; Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan. 8. School of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji, Japan. 9. Department of Psychiatry, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Abstract
OBJECTIVE: To examine whether coenzyme Q10, a potent antioxidant, is associated with risk of dementia, which has not yet been elucidated. APPROACH AND RESULTS: We performed a case-control study nested in a community-based cohort of approximately 6000 Japanese aged 40-69 years at baseline (1984-1994). Serum coenzyme Q10 was measured in 65 incident cases of disabling dementia with dementia-related behavioral disturbance or cognitive impairment incident between 1999 and 2004, and in 130 age-, sex- and baseline year-matched controls. Serum coenzyme Q10 was inversely associated with dementia: the multivariate odds ratios (95% confidence intervals) were 0.68 (0.26-1.78), 0.92 (0.33-2.56), and 0.23 (0.06-0.86) for individuals with the second, third, and highest quartiles of coenzyme Q10, respectively, as compared with the lowest quartile (P for trend = 0.05). A similar association was found for the coenzyme Q10/total cholesterol ratio: the respective ORs were 0.67 (0.25-1.78), 0.73 (0.28-1.92), and 0.21 (0.05-0.90) (P for trend = 0.04). CONCLUSIONS: Serum coenzyme Q10 levels were inversely associated with risk of disabling dementia.
OBJECTIVE: To examine whether coenzyme Q10, a potent antioxidant, is associated with risk of dementia, which has not yet been elucidated. APPROACH AND RESULTS: We performed a case-control study nested in a community-based cohort of approximately 6000 Japanese aged 40-69 years at baseline (1984-1994). Serum coenzyme Q10 was measured in 65 incident cases of disabling dementia with dementia-related behavioral disturbance or cognitive impairment incident between 1999 and 2004, and in 130 age-, sex- and baseline year-matched controls. Serum coenzyme Q10 was inversely associated with dementia: the multivariate odds ratios (95% confidence intervals) were 0.68 (0.26-1.78), 0.92 (0.33-2.56), and 0.23 (0.06-0.86) for individuals with the second, third, and highest quartiles of coenzyme Q10, respectively, as compared with the lowest quartile (P for trend = 0.05). A similar association was found for the coenzyme Q10/total cholesterol ratio: the respective ORs were 0.67 (0.25-1.78), 0.73 (0.28-1.92), and 0.21 (0.05-0.90) (P for trend = 0.04). CONCLUSIONS: Serum coenzyme Q10 levels were inversely associated with risk of disabling dementia.