| Literature DB >> 25462623 |
Jadwiga Paszkowska1, Katarzyna Kral1, Tadeusz Bieg1, Karolina Żaba1, Katarzyna Węgrzyk1, Natalia Jaśkowiak1, Antonio Molinaro2, Alba Silipo2, Ilona Wandzik3.
Abstract
New 5'-glycyl derivatives of uridine containing fragments of varying lipophilicity were synthesized as analogues of natural peptidyl antibiotics. One of the studied compounds, 5'-O-(N-succinylglycyl)-2',3'-O-isopropylideneuridine (A4), showed moderate inhibition against 1,4-β-galactosyltransferase. However, additional studies showed that the observed inhibitory effect was due to binding to bovine serum albumin, which was used in assays as a stabilizer.Entities:
Keywords: Glycosyltransferase inhibitors; Peptidyl nucleoside; Uridine
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Year: 2014 PMID： 25462623 DOI： 10.1016/j.bioorg.2014.11.001
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275