| Literature DB >> 25461900 |
E Dinant Kroese1, Sieto Bosgra2, Harrie E Buist2, Geertje Lewin3, Sander C van der Linden4, Hai-yen Man4, Aldert H Piersma5, Emiel Rorije6, Sjors H W Schulpen7, Michael Schwarz8, Frederik Uibel8, Barbara M A van Vugt-Lussenburg4, Andre P M Wolterbeek2, Bart van der Burg4.
Abstract
Previously we showed a battery consisting of CALUX transcriptional activation assays, the ReProGlo assay, and the embryonic stem cell test, and zebrafish embryotoxicity assay as 'apical' tests to correctly predict developmental toxicity for 11 out of 12 compounds, and to explain the one false negative [7]. Here we report on applying this battery within the context of grouping and read across, put forward as a potential tool to fill data gaps and avoid animal testing, to distinguish in vivo non- or weak developmental toxicants from potent developmental toxicants within groups of structural analogs. The battery correctly distinguished 2-methylhexanoic acid, monomethyl phthalate, and monobutyltin trichloride as non- or weak developmental toxicants from structurally related developmental toxicants valproic acid, mono-ethylhexyl phthalate, and tributyltin chloride, respectively, and, therefore, holds promise as a biological verification model in grouping and read across approaches. The relevance of toxicokinetic information is indicated.Entities:
Keywords: Alternative model; CALUX; Developmental toxicity; Embryonic stem cell test; Grouping; ReProGlo; Read across; Zebrafish embryotoxicity assay
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Year: 2014 PMID： 25461900 DOI： 10.1016/j.reprotox.2014.10.003
Source DB: PubMed Journal: Reprod Toxicol ISSN： 0890-6238 Impact factor: 3.143