Martina Brandizzi1, Frauke Schultze-Lutter2, Alice Masillo3, Andrea Lanna4, Martina Curto5, Juliana Fortes Lindau5, Andrea Solfanelli5, Giulia Listanti3, Martina Patanè3, Giorgio Kotzalidis5, Eva Gebhardt5, Nicholas Meyer6, Diana Di Pietro7, Donato Leccisi7, Paolo Girardi5, Paolo Fiori Nastro3. 1. Neurosciences, Mental Health and Sensory Functions (NESMOS) Department, Sapienza University of Rome, Faculty of Medicine and Psychology, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy; Department of Neurology and Psychiatry, Sapienza University of Rome, Faculty of Medicine and Odontology, Rome 00156, Italy. Electronic address: martina.brandizzi@gmail.com. 2. University Hospital for Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bolligenstr. 111, Haus A 3000 Bern 60, Bern, Switzerland. 3. Department of Neurology and Psychiatry, Sapienza University of Rome, Faculty of Medicine and Odontology, Rome 00156, Italy. 4. Department of Computer, Control, and Management Engineering "A. Ruberti", Sapienza University of Rome, Rome 00185, Italy. 5. Neurosciences, Mental Health and Sensory Functions (NESMOS) Department, Sapienza University of Rome, Faculty of Medicine and Psychology, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy. 6. Institute of Psychiatry, King's College, 16 De Crespigny Park, SE5 8AF London, United Kingdom. 7. Community Mental Health Service, ASL Rome H, 00041 Rome, Italy.
Abstract
OBJECTIVE: Self-rated attenuated psychotic-like experiences (APLEs) are increasingly used to screen for ultra-high-risk (UHR) across all ages. However, self-rated psychotic-like experiences (PLEs), in particular perception-related ones, were more frequent in children and adolescents, in which they possessed less clinical significance. We therefore explored the prevalence of different factors of APLEs in help-seeking adolescents, and their relationship with age, functioning and psychopathology. METHOD: As a part of the "Liberiamo il Futuro" project, help-seeking adolescents (N=171; 11-18 years, 53% male) were screened with the 92-item Prodromal Questionnaire (PQ-92). A factor analysis was performed on the PQ-92 positive items (i.e., APLEs) to identify different APLE-factors. These were assessed for their association with age, functioning and psychopathology using regression analyses. RESULTS: APLEs were very common in help-seeking adolescents, and formed four factors: "Conceptual Disorganization and Suspiciousness", "Perceptual Abnormalities", "Bizarre Experiences", and "Magical Ideation". Associations with age and functioning but not psychopathology were found for "Perceptual Abnormalities" that was significantly more severe in 11-12-year-olds, while "Conceptual Disorganization and Suspiciousness" was significantly related to psychopathology. CONCLUSION: In line with findings on PLEs, prevalence and clinical significance of APLEs, especially perception-related ones, might depend on age and thus neurodevelopmental stage, and may fall within the normal spectrum of experience during childhood. This should be considered when screening for UHR status in younger age groups.
OBJECTIVE: Self-rated attenuated psychotic-like experiences (APLEs) are increasingly used to screen for ultra-high-risk (UHR) across all ages. However, self-rated psychotic-like experiences (PLEs), in particular perception-related ones, were more frequent in children and adolescents, in which they possessed less clinical significance. We therefore explored the prevalence of different factors of APLEs in help-seeking adolescents, and their relationship with age, functioning and psychopathology. METHOD: As a part of the "Liberiamo il Futuro" project, help-seeking adolescents (N=171; 11-18 years, 53% male) were screened with the 92-item Prodromal Questionnaire (PQ-92). A factor analysis was performed on the PQ-92 positive items (i.e., APLEs) to identify different APLE-factors. These were assessed for their association with age, functioning and psychopathology using regression analyses. RESULTS: APLEs were very common in help-seeking adolescents, and formed four factors: "Conceptual Disorganization and Suspiciousness", "Perceptual Abnormalities", "Bizarre Experiences", and "Magical Ideation". Associations with age and functioning but not psychopathology were found for "Perceptual Abnormalities" that was significantly more severe in 11-12-year-olds, while "Conceptual Disorganization and Suspiciousness" was significantly related to psychopathology. CONCLUSION: In line with findings on PLEs, prevalence and clinical significance of APLEs, especially perception-related ones, might depend on age and thus neurodevelopmental stage, and may fall within the normal spectrum of experience during childhood. This should be considered when screening for UHR status in younger age groups.
Authors: Alice Masillo; M Brandizzi; L R Valmaggia; R Saba; N Lo Cascio; J F Lindau; L Telesforo; P Venturini; D Montanaro; D Di Pietro; M D'Alema; P Girardi; P Fiori Nastro Journal: Eur Child Adolesc Psychiatry Date: 2017-09-16 Impact factor: 4.785
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Authors: F Navarro-Mateu; J Alonso; C C W Lim; S Saha; S Aguilar-Gaxiola; A Al-Hamzawi; L H Andrade; E J Bromet; R Bruffaerts; S Chatterji; L Degenhardt; G de Girolamo; P de Jonge; J Fayyad; S Florescu; O Gureje; J M Haro; C Hu; E G Karam; V Kovess-Masfety; S Lee; M E Medina-Mora; A Ojagbemi; B-E Pennell; M Piazza; J Posada-Villa; K M Scott; J C Stagnaro; M Xavier; K S Kendler; R C Kessler; J J McGrath Journal: Acta Psychiatr Scand Date: 2017-05-25 Impact factor: 6.392
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