Mads Lawaetz1, Preben Homøe2. 1. Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University Hospital Copenhagen, Faculty of Health Sciences, Copenhagen, Denmark. Electronic address: Madslawaetz@gmail.com. 2. Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University Hospital Copenhagen, Faculty of Health Sciences, Copenhagen, Denmark.
Abstract
OBJECTIVE: The purpose of this study was to examine which factors are associated with inadequate surgical margins and to assess the postoperative consequences. STUDY DESIGN: A retrospective cohort of 110 patients with oral squamous cell carcinoma treated with surgery during a 2-year period was examined. Clinical, histopathologic, and operative variables were related to the surgical margin status. Furthermore postoperative treatment data were compared with margin status. RESULTS: Univariate statistically significant associations were found between the tumor site in the floor of mouth, more advanced T-stage, increasing tumor thickness, and inadequate margins. Of the patients with involved margins, 87% were treated with postoperative radiotherapy or re-resection, but among patients with close margins, only 35% received either radiotherapy or re-resection. CONCLUSIONS: Clinical and histopathologic factors were associated with the inadequate margin. Postoperative treatment for patients with close margins is controversial, and more studies are needed to define clear guidelines.
OBJECTIVE: The purpose of this study was to examine which factors are associated with inadequate surgical margins and to assess the postoperative consequences. STUDY DESIGN: A retrospective cohort of 110 patients with oral squamous cell carcinoma treated with surgery during a 2-year period was examined. Clinical, histopathologic, and operative variables were related to the surgical margin status. Furthermore postoperative treatment data were compared with margin status. RESULTS: Univariate statistically significant associations were found between the tumor site in the floor of mouth, more advanced T-stage, increasing tumor thickness, and inadequate margins. Of the patients with involved margins, 87% were treated with postoperative radiotherapy or re-resection, but among patients with close margins, only 35% received either radiotherapy or re-resection. CONCLUSIONS: Clinical and histopathologic factors were associated with the inadequate margin. Postoperative treatment for patients with close margins is controversial, and more studies are needed to define clear guidelines.
Authors: Peter A Pellionisz; Nikan K Namiri; Gregory Suematsu; Yong Hu; Ameet Braganza; Khuzaima Rangwalla; Daniel J Denson; Karam Badran; Nathan C Francis; Ashkan Maccabi; George Saddik; Zachary Taylor; Maie A St John; Warren S Grundfest Journal: Yale J Biol Med Date: 2018-09-21