Literature DB >> 25456738

A new biology of diabetes revealed by leptin.

Roger H Unger1, Michael G Roth2.   

Abstract

A variety of leptin actions require a re-examination of classic concepts of metabolic diseases. Here we present evidence for two physiologic pathways: a pathway that protects nonadipose tissues from overaccumulation of potentially toxic lipids and unrecognized paracrine interactions between α and β cells revealed by leptin's ability to suppress diabetic hyperglucagonemia. These observations strongly point to new therapeutic possibilities for both type 1 and type 2 diabetes.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25456738     DOI： 10.1016/j.cmet.2014.10.011

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  15 in total

Review 1.  Intermittent Fasting: Is the Wait Worth the Weight?

Authors:  Mary-Catherine Stockman; Dylan Thomas; Jacquelyn Burke; Caroline M Apovian
Journal:  Curr Obes Rep       Date:  2018-06

2.  A tribute to Roger H. Unger (1924-2020).

Authors:  Philipp E Scherer; Christopher B Newgard
Journal:  J Clin Invest       Date:  2020-12-01       Impact factor: 14.808

3.  Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism.

Authors:  Danny Ben-Zvi; Ornella Barrandon; Stephanie Hadley; Barak Blum; Quinn P Peterson; Douglas A Melton
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-30       Impact factor: 11.205

Review 4.  Mechanisms of the amplifying pathway of insulin secretion in the β cell.

Authors:  Michael A Kalwat; Melanie H Cobb
Journal:  Pharmacol Ther       Date:  2017-05-18       Impact factor: 12.310

5.  Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway.

Authors:  May-Yun Wang; Hai Yan; Zhiqing Shi; Matthew R Evans; Xinxin Yu; Young Lee; Shiuhwei Chen; Annie Williams; Jacques Philippe; Michael G Roth; Roger H Unger
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-09       Impact factor: 11.205

6.  The adverse effects of chronic low-dose exposure to nonylphenol on type 2 diabetes mellitus in high sucrose-high fat diet-treated rats.

Authors:  Jie Yu; Jin Yang; Ya Luo; Yang Mengxue; Wenmei Li; Yu Yang; Liting He; Jie Xu
Journal:  Islets       Date:  2017-12-07       Impact factor: 2.694

Review 7.  Targeting adipose tissue in the treatment of obesity-associated diabetes.

Authors:  Christine M Kusminski; Perry E Bickel; Philipp E Scherer
Journal:  Nat Rev Drug Discov       Date:  2016-06-03       Impact factor: 84.694

Review 8.  Transcriptional and Chromatin Regulation during Fasting - The Genomic Era.

Authors:  Ido Goldstein; Gordon L Hager
Journal:  Trends Endocrinol Metab       Date:  2015-10-29       Impact factor: 12.015

9.  Leptin Production by Encapsulated Adipocytes Increases Brown Fat, Decreases Resistin, and Improves Glucose Intolerance in Obese Mice.

Authors:  David J DiSilvestro; Emiliano Melgar-Bermudez; Rumana Yasmeen; Paolo Fadda; L James Lee; Anuradha Kalyanasundaram; Chen L Gilor; Ouliana Ziouzenkova
Journal:  PLoS One       Date:  2016-04-07       Impact factor: 3.240

10.  Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial.

Authors:  Maelán Fontes-Villalba; Staffan Lindeberg; Yvonne Granfeldt; Filip K Knop; Ashfaque A Memon; Pedro Carrera-Bastos; Óscar Picazo; Madhvi Chanrai; Jan Sunquist; Kristina Sundquist; Tommy Jönsson
Journal:  Cardiovasc Diabetol       Date:  2016-05-23       Impact factor: 9.951
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