Literature DB >> 25456401

Parkinson's disease as a member of Prion-like disorders.

Maria Eugenia Herva1, Maria Grazia Spillantini2.   

Abstract

Parkinson's disease is one of several neurodegenerative diseases associated with a misfolded, aggregated and pathological protein. In Parkinson's disease this protein is alpha-synuclein and its neuronal deposits in the form of Lewy bodies are considered a hallmark of the disease. In this review we describe the clinical and experimental data that have led to think of alpha-synuclein as a prion-like protein and we summarize data from in vitro, cellular and animal models supporting this view.
Copyright © 2014. Published by Elsevier B.V.

Entities:  

Keywords:  Alpha-synuclein; Misfolding; Parkinson; Prion; Spreading

Mesh：

Substances：

Year:  2014        PMID： 25456401     DOI： 10.1016/j.virusres.2014.10.016

Source DB:  PubMed          Journal:  Virus Res        ISSN： 0168-1702            Impact factor:   3.303


  12 in total

1.  From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration.

Authors:  Aram B Cholanians; Andy V Phan; Eric J Ditzel; Todd D Camenisch; Serrine S Lau; Terrence J Monks
Journal:  Toxicol Sci       Date:  2016-07-13       Impact factor: 4.849

Review 2.  Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases.

Authors:  Heiko Braak; Kelly Del Tredici
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-11-01       Impact factor: 10.005

Review 3.  Past, Present, and Future of Non-invasive Brain Stimulation Approaches to Treat Cognitive Impairment in Neurodegenerative Diseases: Time for a Comprehensive Critical Review.

Authors:  Clara Sanches; Chloé Stengel; Juliette Godard; Justine Mertz; Marc Teichmann; Raffaella Migliaccio; Antoni Valero-Cabré
Journal:  Front Aging Neurosci       Date:  2021-01-20       Impact factor: 5.750

4.  Modification of C Terminus Provides New Insights into the Mechanism of α-Synuclein Aggregation.

Authors:  Kseniia Afitska; Anna Fucikova; Volodymyr V Shvadchak; Dmytro A Yushchenko
Journal:  Biophys J       Date:  2017-09-20       Impact factor: 4.033

Review 5.  Prion-like properties of disease-relevant proteins in amyotrophic lateral sclerosis.

Authors:  S Bräuer; V Zimyanin; A Hermann
Journal:  J Neural Transm (Vienna)       Date:  2018-02-08       Impact factor: 3.575

6.  Formation of covalent di-tyrosine dimers in recombinant α-synuclein.

Authors:  A van Maarschalkerweerd; M N Pedersen; H Peterson; M Nilsson; Ttt Nguyen; T Skamris; K Rand; V Vetri; A E Langkilde; B Vestergaard
Journal:  Intrinsically Disord Proteins       Date:  2015-10-19

7.  Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments.

Authors:  Emiel Michiels; Shu Liu; Rodrigo Gallardo; Nikolaos Louros; Marion Mathelié-Guinlet; Yves Dufrêne; Joost Schymkowitz; Ina Vorberg; Frederic Rousseau
Journal:  Cell Rep       Date:  2020-02-25       Impact factor: 9.423

Review 8.  Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives.

Authors:  Tizibt Ashine Bogale; Gaia Faustini; Francesca Longhena; Stefania Mitola; Marina Pizzi; Arianna Bellucci
Journal:  Front Immunol       Date:  2021-02-19       Impact factor: 7.561

9.  Key Points Concerning Amyloid Infectivity and Prion-Like Neuronal Invasion.

Authors:  Alba Espargaró; Maria Antònia Busquets; Joan Estelrich; Raimon Sabate
Journal:  Front Mol Neurosci       Date:  2016-04-22       Impact factor: 5.639

10.  Virus-like particles and enterovirus antigen found in the brainstem neurons of Parkinson's disease.

Authors:  Robert R Dourmashkin; Sherman A McCall; Neil Dourmashkin; Matthew J Hannah
Journal:  F1000Res       Date:  2018-03-09
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