PURPOSE: To examine whether risk factors, including prepregnancy body mass index (BMI), differ between recurrent and incident preeclampsia. METHODS: Data included electronic medical records of nulliparas (n = 26,613) delivering 2 times or more in Utah (2002-2010). Modified Poisson regression models were used to examine (1) adjusted relative risks (RR) of preeclampsia and 95% confidence intervals (CI) associated with prepregnancy BMI; (2) maternal risk factor differences between incident and recurrent preeclampsia among primiparous women. RESULTS: In the first pregnancy, compared with normal weight women (BMI: 18.5-24.9), preeclampsia risks for overweight (BMI: 25-29.9), obese class I (BMI: 30-34.9), and obese class II/III (BMI: ≥ 35) women were 1.82 (95% CI = 1.60-2.06), 2.10 (95% CI = 1.76-2.50), and 2.84 (95% CI = 2.32-3.47), respectively, whereas second pregnancy-incident preeclampsia risks were 1.66 (95% CI = 1.27-2.16), 2.31 (95% CI = 1.67-3.20), and 4.29 (95% CI = 3.16-5.82), respectively. Recurrent preeclampsia risks associated with BMI were highest among obese class I women (RR = 1.60; 95% CI = 1.06-2.42) without increasing in a dose-response manner. Nonwhite women had higher recurrence risk than white women (RR = 1.70; 95% CI = 1.16-2.50), whereas second pregnancy-incident preeclampsia risk did not differ by race. CONCLUSION: Prepregnancy BMI appeared to have stronger associations with risk of incident preeclampsia either in the first or second pregnancy, than with recurrence risk. Nonwhite women had higher recurrence risk.
PURPOSE: To examine whether risk factors, including prepregnancy body mass index (BMI), differ between recurrent and incident preeclampsia. METHODS: Data included electronic medical records of nulliparas (n = 26,613) delivering 2 times or more in Utah (2002-2010). Modified Poisson regression models were used to examine (1) adjusted relative risks (RR) of preeclampsia and 95% confidence intervals (CI) associated with prepregnancy BMI; (2) maternal risk factor differences between incident and recurrent preeclampsia among primiparous women. RESULTS: In the first pregnancy, compared with normal weight women (BMI: 18.5-24.9), preeclampsia risks for overweight (BMI: 25-29.9), obese class I (BMI: 30-34.9), and obese class II/III (BMI: ≥ 35) women were 1.82 (95% CI = 1.60-2.06), 2.10 (95% CI = 1.76-2.50), and 2.84 (95% CI = 2.32-3.47), respectively, whereas second pregnancy-incident preeclampsia risks were 1.66 (95% CI = 1.27-2.16), 2.31 (95% CI = 1.67-3.20), and 4.29 (95% CI = 3.16-5.82), respectively. Recurrent preeclampsia risks associated with BMI were highest among obese class I women (RR = 1.60; 95% CI = 1.06-2.42) without increasing in a dose-response manner. Nonwhite women had higher recurrence risk than white women (RR = 1.70; 95% CI = 1.16-2.50), whereas second pregnancy-incident preeclampsia risk did not differ by race. CONCLUSION: Prepregnancy BMI appeared to have stronger associations with risk of incident preeclampsia either in the first or second pregnancy, than with recurrence risk. Nonwhite women had higher recurrence risk.
Authors: Darios Getahun; Cande V Ananth; Yinka Oyelese; Martin R Chavez; Russell S Kirby; John C Smulian Journal: Obstet Gynecol Date: 2007-12 Impact factor: 7.623
Authors: Candace Tannis; Rachel Fletcher-Slater; Inessa Lopez; Alexandrah Gichingiri; Mario Cassara; Susanne Lachapelle; Elizabeth Garland Journal: Int Public Health J Date: 2018-10-01
Authors: Mary E D'Alton; Alexander M Friedman; Peter S Bernstein; Haywood L Brown; William M Callaghan; Steven L Clark; William A Grobman; Sarah J Kilpatrick; Daniel F O'Keeffe; Douglas M Montgomery; Sindhu K Srinivas; George D Wendel; Katharine D Wenstrom; Michael R Foley Journal: Am J Obstet Gynecol Date: 2019-03-05 Impact factor: 8.661
Authors: Pauline Mendola; Akhgar Ghassabian; James L Mills; Cuilin Zhang; Michael Y Tsai; Aiyi Liu; Edwina H Yeung Journal: Am J Hypertens Date: 2017-06-01 Impact factor: 2.689
Authors: Tamara Garrido-Gomez; Francisco Dominguez; Alicia Quiñonero; Patricia Diaz-Gimeno; Mirhan Kapidzic; Matthew Gormley; Katherine Ona; Pablo Padilla-Iserte; Michael McMaster; Olga Genbacev; Alfredo Perales; Susan J Fisher; Carlos Simón Journal: Proc Natl Acad Sci U S A Date: 2017-09-18 Impact factor: 11.205
Authors: Mary Catherine Tolcher; Derrick M Chu; Lisa M Hollier; Joan M Mastrobattista; Diana A Racusin; Susan M Ramin; Haleh Sangi-Haghpeykar; Kjersti M Aagaard Journal: Am J Obstet Gynecol Date: 2017-04-25 Impact factor: 8.661
Authors: Christine Maric-Bilkan; Vikki M Abrahams; S Sonia Arteaga; Ghada Bourjeily; Kirk P Conrad; Janet M Catov; Maged M Costantine; Brian Cox; Vesna Garovic; Eric M George; Alison D Gernand; Arun Jeyabalan; S Ananth Karumanchi; Aaron D Laposky; Menachem Miodovnik; Megan Mitchell; Victoria L Pemberton; Uma M Reddy; Mark K Santillan; Eleni Tsigas; Kent L R Thornburg; Kenneth Ward; Leslie Myatt; James M Roberts Journal: Hypertension Date: 2019-04 Impact factor: 10.190