Literature DB >> 25450978

Fe-S proteins that regulate gene expression.

Erin L Mettert1, Patricia J Kiley2.   

Abstract

Iron-sulfur (Fe-S) cluster containing proteins that regulate gene expression are present in most organisms. The innate chemistry of their Fe-S cofactors makes these regulatory proteins ideal for sensing environmental signals, such as gases (e.g. O2 and NO), levels of Fe and Fe-S clusters, reactive oxygen species, and redox cycling compounds, to subsequently mediate an adaptive response. Here we review the recent findings that have provided invaluable insight into the mechanism and function of these highly significant Fe-S regulatory proteins. This article is part of a Special Issue entitled: Fe/S proteins: Analysis, structure, function, biogenesis and diseases.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Gene expression; Iron–sulfur (Fe–S) cluster; Regulatory protein; Sensor; Transcription factor

Mesh:

Substances:

Year:  2014        PMID: 25450978      PMCID: PMC4390428          DOI: 10.1016/j.bbamcr.2014.11.018

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  189 in total

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Journal:  J Bacteriol       Date:  2001-08       Impact factor: 3.490

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6.  UvrC Coordinates an O2-Sensitive [4Fe4S] Cofactor.

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10.  Identification of a PadR-type regulator essential for intracellular pathogenesis of Burkholderia pseudomallei.

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