Literature DB >> 25449131

Adenosine activates thermogenic adipocytes.

Amy K Rines1, Francisco Verdeguer1, Pere Puigserver1.   

Abstract

Brown or beige fat activation can cause potent anti-obesity and anti-diabetic effects. In a study recently published in Nature, Gnad et al. show that adenosine is a novel activator of brown and beige fat that acts through the A2A receptor.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25449131      PMCID： PMC4650567          DOI： 10.1038/cr.2014.157

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  11 in total

Review 1.  Towards a molecular understanding of adaptive thermogenesis.

Authors:  B B Lowell; B M Spiegelman
Journal:  Nature       Date:  2000-04-06       Impact factor: 49.962

Review 2.  Brown adipose tissue, beta 3-adrenergic receptors, and obesity.

Authors:  B B Lowell; J S Flier
Journal:  Annu Rev Med       Date:  1997       Impact factor: 13.739

Review 3.  International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update.

Authors:  Bertil B Fredholm; Adriaan P IJzerman; Kenneth A Jacobson; Joel Linden; Christa E Müller
Journal:  Pharmacol Rev       Date:  2011-02-08       Impact factor: 25.468

4.  A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

Authors:  P Puigserver; Z Wu; C W Park; R Graves; M Wright; B M Spiegelman
Journal:  Cell       Date:  1998-03-20       Impact factor: 41.582

5.  Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor.

Authors:  B Johansson; L Halldner; T V Dunwiddie; S A Masino; W Poelchen; L Giménez-Llort; R M Escorihuela; A Fernández-Teruel; Z Wiesenfeld-Hallin; X J Xu; A Hårdemark; C Betsholtz; E Herlenius; B B Fredholm
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-24       Impact factor: 11.205

6.  Effects of adenosine nucleosides on adenylate cyclase, phosphodiesterase, cyclic adenosine monophosphate accumulation, and lipolysis in fat cells.

Authors:  J N Fain; R H Pointer; W F Ward
Journal:  J Biol Chem       Date:  1972-11-10       Impact factor: 5.157

7.  Adenosine receptors mediating cyclic AMP production in the rat hippocampus.

Authors:  B B Fredholm; B Jonzon; E Lindgren; K Lindström
Journal:  J Neurochem       Date:  1982-07       Impact factor: 5.372

8.  Role of adenosine as an endogenous regulator of respiration in hamster brown adipocytes.

Authors:  R J Schimmel; L McCarthy
Journal:  Am J Physiol       Date:  1984-03

Review 9.  A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis.

Authors:  Shingo Kajimura; Masayuki Saito
Journal:  Annu Rev Physiol       Date:  2013-11-04       Impact factor: 19.318

10.  Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinase.

Authors:  T Kleppisch; M T Nelson
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-19       Impact factor: 11.205
View more
  2 in total

Review 1.  Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus.

Authors:  Adilson Guilherme; Felipe Henriques; Alexander H Bedard; Michael P Czech
Journal:  Nat Rev Endocrinol       Date:  2019-04       Impact factor: 43.330

Review 2.  The involvement of purinergic signalling in obesity.

Authors:  Geoffrey Burnstock; Daniela Gentile
Journal:  Purinergic Signal       Date:  2018-04-04       Impact factor: 3.765
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.