Literature DB >> 24188710

A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis.

Shingo Kajimura1, Masayuki Saito.   

Abstract

Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat as a defense against cold and excessive feeding. Interest in the field of BAT biology has exploded in the past few years because of the therapeutic potential of BAT to counteract obesity and obesity-related diseases, including insulin resistance. Much progress has been made, particularly in the areas of BAT physiology in adult humans, developmental lineages of brown adipose cell fate, and hormonal control of BAT thermogenesis. As we enter into a new era of brown fat biology, the next challenge will be to develop strategies for activating BAT thermogenesis in adult humans to increase whole-body energy expenditure. This article reviews the recent major advances in this field and discusses emerging questions.

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Year:  2013        PMID： 24188710      PMCID： PMC4090362          DOI： 10.1146/annurev-physiol-021113-170252

Source DB:  PubMed          Journal:  Annu Rev Physiol        ISSN： 0066-4278            Impact factor:   19.318


  146 in total

1.  Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes.

Authors:  J Himms-Hagen; A Melnyk; M C Zingaretti; E Ceresi; G Barbatelli; S Cinti
Journal:  Am J Physiol Cell Physiol       Date:  2000-09       Impact factor: 4.249

2.  Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.

Authors:  Kristin I Stanford; Roeland J W Middelbeek; Kristy L Townsend; Ding An; Eva B Nygaard; Kristen M Hitchcox; Kathleen R Markan; Kazuhiro Nakano; Michael F Hirshman; Yu-Hua Tseng; Laurie J Goodyear
Journal:  J Clin Invest       Date:  2012-12-10       Impact factor: 14.808

Review 3.  Adaptive thermogenesis in adipocytes: is beige the new brown?

Authors:  Jun Wu; Paul Cohen; Bruce M Spiegelman
Journal:  Genes Dev       Date:  2013-02-01       Impact factor: 11.361

4.  MyomiR-133 regulates brown fat differentiation through Prdm16.

Authors:  Mirko Trajkovski; Kashan Ahmed; Christine C Esau; Markus Stoffel
Journal:  Nat Cell Biol       Date:  2012-12       Impact factor: 28.824

Review 5.  Capsinoids and related food ingredients activating brown fat thermogenesis and reducing body fat in humans.

Authors:  Masayuki Saito; Takeshi Yoneshiro
Journal:  Curr Opin Lipidol       Date:  2013-02       Impact factor: 4.776

6.  BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis.

Authors:  Shu-Wen Qian; Yan Tang; Xi Li; Yuan Liu; You-You Zhang; Hai-Yan Huang; Rui-Dan Xue; Hao-Yong Yu; Liang Guo; Hui-Di Gao; Yan Liu; Xia Sun; Yi-Ming Li; Wei-Ping Jia; Qi-Qun Tang
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-06       Impact factor: 11.205

7.  Characterization of human brown adipose tissue by chemical-shift water-fat MRI.

Authors:  Houchun H Hu; Thomas G Perkins; Jonathan M Chia; Vicente Gilsanz
Journal:  AJR Am J Roentgenol       Date:  2013-01       Impact factor: 3.959

8.  Ephedrine activates brown adipose tissue in lean but not obese humans.

Authors:  A L Carey; M F Formosa; B Van Every; D Bertovic; N Eikelis; G W Lambert; V Kalff; S J Duffy; M H Cherk; B A Kingwell
Journal:  Diabetologia       Date:  2012-10-13       Impact factor: 10.122

9.  Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals.

Authors:  Sohei Tsukita; Tetsuya Yamada; Kenji Uno; Kei Takahashi; Keizo Kaneko; Yasushi Ishigaki; Junta Imai; Yutaka Hasegawa; Shojiro Sawada; Hisamitsu Ishihara; Yoshitomo Oka; Hideki Katagiri
Journal:  Cell Metab       Date:  2012-12-05       Impact factor: 27.287

10.  Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs.

Authors:  Claudio J Villanueva; Laurent Vergnes; Jiexin Wang; Brian G Drew; Cynthia Hong; Yiping Tu; Yan Hu; Xu Peng; Feng Xu; Enrique Saez; Kevin Wroblewski; Andrea L Hevener; Karen Reue; Loren G Fong; Stephen G Young; Peter Tontonoz
Journal:  Cell Metab       Date:  2013-03-05       Impact factor: 27.287
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  166 in total

1.  Prostaglandin E2 signals white-to-brown adipogenic differentiation.

Authors:  Verónica García-Alonso; Joan Clària
Journal:  Adipocyte       Date:  2014-12-10       Impact factor: 4.534

2.  Aryl hydrocarbon receptor deficiency protects mice from diet-induced adiposity and metabolic disorders through increased energy expenditure.

Authors:  Can-Xin Xu; Chun Wang; Zhi-Ming Zhang; Cassie D Jaeger; Stacey L Krager; Kathleen M Bottum; Jianghua Liu; Duan-Fang Liao; Shelley A Tischkau
Journal:  Int J Obes (Lond)       Date:  2015-04-24       Impact factor: 5.095

3.  Lipodystrophy HIV-related and FGF21: A new marker to follow the progression of lipodystrophy?

Authors:  Stefano Benedini; Livio Luzi
Journal:  J Transl Int Med       Date:  2016-12-30

Review 4.  Mitochondrial homeostasis in adipose tissue remodeling.

Authors:  Svetlana Altshuler-Keylin; Shingo Kajimura
Journal:  Sci Signal       Date:  2017-02-28       Impact factor: 8.192

Review 5.  Involvement of thermosensitive TRP channels in energy metabolism.

Authors:  Kunitoshi Uchida; Katsuya Dezaki; Takeshi Yoneshiro; Tatsuo Watanabe; Jun Yamazaki; Masayuki Saito; Toshihiko Yada; Makoto Tominaga; Yusaku Iwasaki
Journal:  J Physiol Sci       Date:  2017-06-27       Impact factor: 2.781

Review 6.  Brown Adipose Tissue (BAT) detection by 18F-FDG PET and thyroid hormone level(s)-a systematic review.

Authors:  Prasanna Santhanam; Rexford S Ahima; Jennifer S Mammen; Luca Giovanella; Giorgio Treglia
Journal:  Endocrine       Date:  2018-07-31       Impact factor: 3.633

7.  MRI characterization of brown adipose tissue under thermal challenges in normal weight, overweight, and obese young men.

Authors:  Jie Deng; Lisa M Neff; Nicholas C Rubert; Bin Zhang; Richard M Shore; Jonathan D Samet; Paige C Nelson; Lewis Landsberg
Journal:  J Magn Reson Imaging       Date:  2017-08-11       Impact factor: 4.813

Review 8.  Beyond the bone: Bone morphogenetic protein signaling in adipose tissue.

Authors:  Ana M Blázquez-Medela; Medet Jumabay; Kristina I Boström
Journal:  Obes Rev       Date:  2019-01-04       Impact factor: 9.213

9.  Effects of tunable, 3D-bioprinted hydrogels on human brown adipocyte behavior and metabolic function.

Authors:  Mitchell Kuss; Jiyoung Kim; Dianjun Qi; Shaohua Wu; Yuguo Lei; Soonkyu Chung; Bin Duan
Journal:  Acta Biomater       Date:  2018-03-16       Impact factor: 8.947

Review 10.  Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis.

Authors:  Labros Sidossis; Shingo Kajimura
Journal:  J Clin Invest       Date:  2015-02-02       Impact factor: 14.808
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