| Literature DB >> 25448755 |
Uma Do J P Rai1, Simon A Young1, Thilini R Thrimawithana1, Hamdy Abdelkader2, Adam W G Alani3, Barbara Pierscionek4, Raid G Alany5.
Abstract
The development of safe and convenient drug delivery strategies for treatment of posterior segment eye diseases is challenging. Although intravitreal injection has wide acceptance amongst clinicians, its use is associated with serious side-effects. Recently, the suprachoroidal space (SCS) has attracted the attention of ophthalmologists and pharmaceutical formulators as a potential site for drug administration and delivery to the posterior segment of the eye. This review highlights the major constraints of drug delivery to the posterior eye segment, key anatomical and physiological features of the SCS and drug delivery applications of this route with emphasis on microneedles along with future perspectives.Entities:
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Year: 2014 PMID： 25448755 DOI： 10.1016/j.drudis.2014.10.010
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851