Literature DB >> 25448295

Building the Connectivity Map of epigenetics: chromatin profiling by quantitative targeted mass spectrometry.

Amanda L Creech1, Jordan E Taylor1, Verena K Maier2, Xiaoyun Wu1, Caitlin M Feeney1, Namrata D Udeshi1, Sally E Peach1, Jesse S Boehm1, Jeannie T Lee3, Steven A Carr1, Jacob D Jaffe4.   

Abstract

Epigenetic control of genome function is an important regulatory mechanism in diverse processes such as lineage commitment and environmental sensing, and in disease etiologies ranging from neuropsychiatric disorders to cancer. Here we report a robust, high-throughput targeted, quantitative mass spectrometry (MS) method to rapidly profile modifications of the core histones of chromatin that compose the epigenetic landscape, enabling comparisons among cells with differing genetic backgrounds, genomic perturbations, and drug treatments.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Chromatin; Epigenetics; Histones; Mass spectrometry; Proteomics; SILAC

Mesh：

Substances：

Year:  2014        PMID： 25448295      PMCID： PMC4300274          DOI： 10.1016/j.ymeth.2014.10.033

Source DB:  PubMed          Journal:  Methods        ISSN： 1046-2023            Impact factor:   3.608


  13 in total

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3.  The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.

Authors:  Justin Lamb; Emily D Crawford; David Peck; Joshua W Modell; Irene C Blat; Matthew J Wrobel; Jim Lerner; Jean-Philippe Brunet; Aravind Subramanian; Kenneth N Ross; Michael Reich; Haley Hieronymus; Guo Wei; Scott A Armstrong; Stephen J Haggarty; Paul A Clemons; Ru Wei; Steven A Carr; Eric S Lander; Todd R Golub
Journal:  Science       Date:  2006-09-29       Impact factor: 47.728

4.  Chemical derivatization of histones for facilitated analysis by mass spectrometry.

Authors:  Benjamin A Garcia; Sahana Mollah; Beatrix M Ueberheide; Scott A Busby; Tara L Muratore; Jeffrey Shabanowitz; Donald F Hunt
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5.  Arid4b is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit.

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