Elisa Cinotti1, Jean-Luc Perrot2, Bruno Labeille2, Nelly Campolmi3, Marine Espinasse3, Damien Grivet3, Gilles Thuret4, Philippe Gain3, Catherine Douchet5, Caroline Andrea2, Maher Haouas6, Frédéric Cambazard2. 1. Department of Dermatology, University Hospital of Saint-Etienne, Saint-Etienne, France. Electronic address: elisacinotti@gmail.com. 2. Department of Dermatology, University Hospital of Saint-Etienne, Saint-Etienne, France. 3. Department of Ophthalmology, University Hospital of Saint-Etienne, Saint-Etienne, France; Biology, Engineering and Imaging of Corneal Graft Laboratory, EA2521, Jean Monnet University, Saint-Etienne, France. 4. Department of Ophthalmology, University Hospital of Saint-Etienne, Saint-Etienne, France; Biology, Engineering and Imaging of Corneal Graft Laboratory, EA2521, Jean Monnet University, Saint-Etienne, France; Institut Universitaire de France, Paris, France. 5. Department of Pathology, University Hospital of Saint-Etienne, Saint-Etienne, France. 6. Department of Ophthalmology, University Hospital of Saint-Etienne, Saint-Etienne, France.
Abstract
PURPOSE: To evaluate whether the handheld in vivo reflectance confocal microscopy that has been recently developed for the study of skin tumors is suitable for the diagnosis of conjunctival tumors. DESIGN: Prospective study, observational case series. METHODS: We prospectively evaluated the reflectance confocal microscopy features of 53 conjunctival lesions clinically suspicious for tumors of 46 patients referred to the University Hospital of Saint-Etienne (France) by using the handheld device. Twenty-three lesions were excised (3 nevi, 10 melanomas, 5 squamous cell carcinoma, 2 lymphomas, and 3 pinguecula/pterygium) while the other 30, presenting no reflectance confocal microscopy malignant features, were under follow-up for at least 1 year. Clinical reflectance confocal microscopy and histologic diagnosis were compared. RESULTS: In vivo reflectance confocal microscopy diagnosis was in agreement with the histologic diagnosis in all cases and none of the lesions that were not excised show any clinical progression under follow-up. CONCLUSION: In vivo reflectance confocal microscopy with a handheld dermatology-dedicated microscope can play a role in the noninvasive diagnosis of conjunctival lesions. Further studies should be performed to better define the diagnostic ability of this technique.
PURPOSE: To evaluate whether the handheld in vivo reflectance confocal microscopy that has been recently developed for the study of skin tumors is suitable for the diagnosis of conjunctival tumors. DESIGN: Prospective study, observational case series. METHODS: We prospectively evaluated the reflectance confocal microscopy features of 53 conjunctival lesions clinically suspicious for tumors of 46 patients referred to the University Hospital of Saint-Etienne (France) by using the handheld device. Twenty-three lesions were excised (3 nevi, 10 melanomas, 5 squamous cell carcinoma, 2 lymphomas, and 3 pinguecula/pterygium) while the other 30, presenting no reflectance confocal microscopy malignant features, were under follow-up for at least 1 year. Clinical reflectance confocal microscopy and histologic diagnosis were compared. RESULTS: In vivo reflectance confocal microscopy diagnosis was in agreement with the histologic diagnosis in all cases and none of the lesions that were not excised show any clinical progression under follow-up. CONCLUSION: In vivo reflectance confocal microscopy with a handheld dermatology-dedicated microscope can play a role in the noninvasive diagnosis of conjunctival lesions. Further studies should be performed to better define the diagnostic ability of this technique.
Authors: Jesús Z Villarreal; J Pérez-Anker; Luis F Quintana; A García-Herrera; S Puig; G Pellacani; M Solé; J Malvehy Journal: J Nephrol Date: 2020-09-02 Impact factor: 3.902