Literature DB >> 2544653

Neutrophil oxidative metabolism after exposure to bacterial phospholipase C.

B Styrt1, R D Walker, J C White.   

Abstract

The effects of phospholipase C (PLC) from Clostridium perfringens and Bacillus cereus on bovine neutrophil oxidative metabolism were studied by measuring superoxide production and oxygen consumption in response to PLC alone or in combination with other stimuli. PLC from both species elicited superoxide production and enhanced the response to stimulation by NaF when the two stimuli were given simultaneously. However, oxygen consumption in response to latex beads was markedly inhibited by pretreatment of cells with B. cereus PLC. The results suggest that some bacterial PLC exoenzymes may initially activate neutrophils but leave the cells relatively unresponsive to subsequent stimuli.

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Year:  1989        PMID： 2544653

Source DB:  PubMed          Journal:  J Lab Clin Med        ISSN： 0022-2143


  6 in total

1.  Degranulation of human neutrophils after exposure to bacterial phospholipase C.

Authors:  T K Wazny; N Mummaw; B Styrt
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1990-11       Impact factor: 3.267

2.  Signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils.

Authors:  Masataka Oda; Syusuke Ikari; Takayuki Matsuno; Yuka Morimune; Masahiro Nagahama; Jun Sakurai
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

Review 3.  Virulence factors of the family Legionellaceae.

Authors:  J N Dowling; A K Saha; R H Glew
Journal:  Microbiol Rev       Date:  1992-03

Review 4.  Bacterial phospholipases C.

Authors:  R W Titball
Journal:  Microbiol Rev       Date:  1993-06

5.  Listeriolysin O suppresses phospholipase C-mediated activation of the microbicidal NADPH oxidase to promote Listeria monocytogenes infection.

Authors:  Grace Y Lam; Ramzi Fattouh; Aleixo M Muise; Sergio Grinstein; Darren E Higgins; John H Brumell
Journal:  Cell Host Microbe       Date:  2011-12-15       Impact factor: 21.023

6.  Role of alpha-toxin in Clostridium perfringens infection determined by using recombinants of C. perfringens and Bacillus subtilis.

Authors:  M Ninomiya; O Matsushita; J Minami; H Sakamoto; M Nakano; A Okabe
Journal:  Infect Immun       Date:  1994-11       Impact factor: 3.441
  6 in total

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