Literature DB >> 25446315

Spatially resolved transcriptomics and beyond.

Nicola Crosetto1, Magda Bienko1, Alexander van Oudenaarden2.   

Abstract

Considerable progress in sequencing technologies makes it now possible to study the genomic and transcriptomic landscape of single cells. However, to better understand the complexity of multicellular organisms, we must devise ways to perform high-throughput measurements while preserving spatial information about the tissue context or subcellular localization of analysed nucleic acids. In this Innovation article, we summarize pioneering technologies that enable spatially resolved transcriptomics and discuss how these methods have the potential to extend beyond transcriptomics to encompass spatially resolved genomics, proteomics and possibly other omic disciplines.

Mesh：

Year:  2014        PMID： 25446315     DOI： 10.1038/nrg3832

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  95 in total

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