| Literature DB >> 25446238 |
You-Min Ying1, Lin-Yan Zhang1, Xia Zhang2, Hai-Bo Bai2, Dong-E Liang1, Lie-Feng Ma1, Wei-Guang Shan3, Zha-Jun Zhan4.
Abstract
Lanostane-type triterpenoids, inotolactones A and B, a drimane-type sesquiterpenoid, inotolactone C, and five known terpenoids 6β-hydroxy-trans-dihydroconfertifolin, inotodiol, 3β,22-dihydroxyanosta-7,9(11),24-triene, 3β-hydroxycinnamolide, and 17-hydroxy-ent-atisan-19-oic acid, were isolated from the submerged culture of chaga mushroom, Inonotus obliquus. Their structures were characterized by spectroscopic methods, including MS and NMR (1D and 2D) spectroscopic techniques. Inotolactones A and B, examples of lanostane-type triterpenoids bearing α,β-dimethyl, α,β-unsaturated δ-lactone side chains, exhibited more potent alpha-glucosidase inhibitory activities than the positive control acarbose. This finding might be related to the anti-hyperglycemic properties of the fungus and to its popular role as a diabetes treatment. In addition, a drimane-type sesquiterpenoid and an atisane-type diterpenoid were isolated from I. obliquus.Entities:
Keywords: Alpha-glucosidase; Chaga mushroom; Drimane; Hymenochaetaceae; Inonotus obliquus; Lanostane; Triterpenoids
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Year: 2014 PMID： 25446238 DOI： 10.1016/j.phytochem.2014.09.022
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072