Ho Sung Lee1, Yunsung Nam1, Yoon Hee Chung2, Hak Rim Kim3, Eon Sub Park4, Su Jin Chung1, Jung Hyo Kim5, Uy Dong Sohn5, Hyoung-Chun Kim6, Keon Woong Oh7, Ji Hoon Jeong8. 1. Department of Pharmacology, College of Medicine, Chung-ang University, Seoul 156-756, Republic of Korea. 2. Department of Anatomy, College of Medicine, Chung-ang University, Seoul 156-756, Republic of Korea. 3. Department of Pharmacology, College of Medicine, Dankook University, Chungnam, Republic of Korea. 4. Departments of Pathology, College of Medicine, Chung-ang University, Seoul 156-756, Republic of Korea. 5. Department of Pharmacology, College of Pharmacy, Chung-ang University, Seoul 156-756, Republic of Korea. 6. Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, Republic of Korea. 7. Departments of Pathology, College of Medicine, Chung-ang University, Seoul 156-756, Republic of Korea; Christmas clinic, Sin-gal-dong, Giheung-gu, Yongin-si, Gyeonggi-do, Republic of Korea. 8. Department of Pharmacology, College of Medicine, Chung-ang University, Seoul 156-756, Republic of Korea. Electronic address: jhjeong3@cau.ac.kr.
Abstract
AIMS: Soybean-derived PC is an essential cell membrane phospholipid that is composed of unsaturated fatty acids, including oleic acid. The present study aimed to evaluate the potential alleviation effects of soybean PC on high fat diet (HFD)-induced obesity and its related complications. MAIN METHODS: We fed C57BL/6 mice a HFD for 12 weeks and administered PC orally for 8 or 12 weeks at different doses. At the end of the experiment, blood was prepared for biochemical analysis and leptin ELISA. Aorta, epididymal and mesenteric fat and liver were removed surgically, weighed and observed for histological or immunohistochemical changes. KEY FINDINGS: PC significantly prevented body weight gain and lipid accumulation and alleviated hyperlipidemia by decreasing triglyceride (TG) and total cholesterol (TC) levels and the atherogenic index in serum or by increasing the HDL/TC ratio. Aortic apoE expression and serum leptin levels were suppressed by PC treatment in the HFD-induced obese mouse model. Elevated serum aspartate aminotransferase and alanine aminotransferase levels in HFD-fed mice were decreased in the PC groups. PC treatment significantly decreased HFD-induced liver weight and hepatic lipid accumulation. SIGNIFICANCE: PC treatment alleviated HFD-induced obese status and obesity-related complications such as hyperlipidemic changes that induce cardiovascular disease and NAFLD.
AIMS: Soybean-derived PC is an essential cell membrane phospholipid that is composed of unsaturated fatty acids, including oleic acid. The present study aimed to evaluate the potential alleviation effects of soybeanPC on high fat diet (HFD)-induced obesity and its related complications. MAIN METHODS: We fed C57BL/6 mice a HFD for 12 weeks and administered PC orally for 8 or 12 weeks at different doses. At the end of the experiment, blood was prepared for biochemical analysis and leptin ELISA. Aorta, epididymal and mesenteric fat and liver were removed surgically, weighed and observed for histological or immunohistochemical changes. KEY FINDINGS:PC significantly prevented body weight gain and lipid accumulation and alleviated hyperlipidemia by decreasing triglyceride (TG) and total cholesterol (TC) levels and the atherogenic index in serum or by increasing the HDL/TC ratio. Aortic apoE expression and serum leptin levels were suppressed by PC treatment in the HFD-induced obesemouse model. Elevated serum aspartate aminotransferase and alanine aminotransferase levels in HFD-fed mice were decreased in the PC groups. PC treatment significantly decreased HFD-induced liver weight and hepatic lipid accumulation. SIGNIFICANCE: PC treatment alleviated HFD-induced obese status and obesity-related complications such as hyperlipidemic changes that induce cardiovascular disease and NAFLD.
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