Felipe A Medeiros1, Carolina P B Gracitelli2, Erwin R Boer3, Robert N Weinreb3, Linda M Zangwill3, Peter N Rosen3. 1. Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California. Electronic address: fmedeiros@ucsd.edu. 2. Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California; Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. 3. Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Abstract
PURPOSE: To evaluate the association between longitudinal changes in quality of life (QoL) and rates of progressive visual field loss in glaucoma. DESIGN: Prospective observational cohort study. PARTICIPANTS: We recruited 322 eyes of 161 patients with glaucomatous visual field loss from the Diagnostic Innovations Glaucoma Study followed for an average of 3.5±0.7 years. METHODS: All subjects had National Eye Institute Visual Function Questionnaire (NEI VFQ)-25 performed annually and standard automated perimetry (SAP) at 6-month intervals. Subjects were included if they had a minimum of 2 NEI VFQ-25 and ≥5 SAP during follow-up. Evaluation of rates of visual field change was performed using the mean sensitivity (MS) of the integrated binocular visual field (BVF). Rasch analysis was performed to obtain final scores of disability as measured by the NEI VFQ-25. A joint longitudinal multivariate mixed model was used to investigate the association between change in NEI VFQ-25 Rasch-calibrated scores and change in BVF sensitivity. Potentially confounding socioeconomic and clinical variables also were analyzed. MAIN OUTCOME MEASURES: The relationship between change in NEI VFQ-25 Rasch-calibrated scores and change in binocular SAP MS. RESULTS: There was a significant correlation between change in the NEI VFQ-25 Rasch scores during follow-up and change in binocular SAP sensitivity. Each 1-dB change in binocular SAP MS per year was associated with a change of 2.9 units per year in the NEI VFQ-25 Rasch scores during the follow-up period (R(2) = 26%; P<0.001). Eyes with more severe disease at baseline were also more likely to have a decrease in NEI VFQ-25 scores during follow-up (P<0.001). For subjects with the same amount of change in SAP sensitivity, those with shorter follow-up times had larger changes in NEI VFQ-25 scores (P = 0.005). A multivariable model containing baseline and rate of change in binocular MS had an adjusted R(2) of 50% in predicting change in NEI VFQ-25 scores. CONCLUSIONS: Baseline severity, magnitude, and rates of change in BVF sensitivity were associated with longitudinal changes in QoL of glaucoma patients. Assessment of longitudinal visual field changes may help to identify patients at greater risk for developing disability from the disease.
PURPOSE: To evaluate the association between longitudinal changes in quality of life (QoL) and rates of progressive visual field loss in glaucoma. DESIGN: Prospective observational cohort study. PARTICIPANTS: We recruited 322 eyes of 161 patients with glaucomatous visual field loss from the Diagnostic Innovations Glaucoma Study followed for an average of 3.5±0.7 years. METHODS: All subjects had National Eye Institute Visual Function Questionnaire (NEI VFQ)-25 performed annually and standard automated perimetry (SAP) at 6-month intervals. Subjects were included if they had a minimum of 2 NEI VFQ-25 and ≥5 SAP during follow-up. Evaluation of rates of visual field change was performed using the mean sensitivity (MS) of the integrated binocular visual field (BVF). Rasch analysis was performed to obtain final scores of disability as measured by the NEI VFQ-25. A joint longitudinal multivariate mixed model was used to investigate the association between change in NEI VFQ-25 Rasch-calibrated scores and change in BVF sensitivity. Potentially confounding socioeconomic and clinical variables also were analyzed. MAIN OUTCOME MEASURES: The relationship between change in NEI VFQ-25 Rasch-calibrated scores and change in binocular SAP MS. RESULTS: There was a significant correlation between change in the NEI VFQ-25 Rasch scores during follow-up and change in binocular SAP sensitivity. Each 1-dB change in binocular SAP MS per year was associated with a change of 2.9 units per year in the NEI VFQ-25 Rasch scores during the follow-up period (R(2) = 26%; P<0.001). Eyes with more severe disease at baseline were also more likely to have a decrease in NEI VFQ-25 scores during follow-up (P<0.001). For subjects with the same amount of change in SAP sensitivity, those with shorter follow-up times had larger changes in NEI VFQ-25 scores (P = 0.005). A multivariable model containing baseline and rate of change in binocular MS had an adjusted R(2) of 50% in predicting change in NEI VFQ-25 scores. CONCLUSIONS: Baseline severity, magnitude, and rates of change in BVF sensitivity were associated with longitudinal changes in QoL of glaucomapatients. Assessment of longitudinal visual field changes may help to identify patients at greater risk for developing disability from the disease.
Authors: Lyne Racette; Jeffrey M Liebmann; Christopher A Girkin; Linda M Zangwill; Sonia Jain; Lida M Becerra; Felipe A Medeiros; Christopher Bowd; Robert N Weinreb; Catherine Boden; Pamela A Sample Journal: Arch Ophthalmol Date: 2010-05
Authors: Felipe A Medeiros; Linda M Zangwill; Luciana M Alencar; Pamela A Sample; Robert N Weinreb Journal: Am J Ophthalmol Date: 2010-04-08 Impact factor: 5.258
Authors: Roberta McKean-Cowdin; Rohit Varma; Ron D Hays; Joanne Wu; Farzana Choudhury; Stanley P Azen Journal: Ophthalmology Date: 2010-06-08 Impact factor: 12.079
Authors: Pamela A Sample; Christopher A Girkin; Linda M Zangwill; Sonia Jain; Lyne Racette; Lida M Becerra; Robert N Weinreb; Felipe A Medeiros; M Roy Wilson; Julio De León-Ortega; Celso Tello; Christopher Bowd; Jeffrey M Liebmann Journal: Arch Ophthalmol Date: 2009-09
Authors: Felipe A Medeiros; Luciana M Alencar; Linda M Zangwill; Christopher Bowd; Pamela A Sample; Robert N Weinreb Journal: Arch Ophthalmol Date: 2009-10
Authors: Luciana M Alencar; Linda M Zangwill; Robert N Weinreb; Christopher Bowd; Gianmarco Vizzeri; Pamela A Sample; Remo Susanna; Felipe A Medeiros Journal: Ophthalmology Date: 2009-12-24 Impact factor: 12.079
Authors: Carolina P B Gracitelli; Ricardo Y Abe; Andrew J Tatham; Peter N Rosen; Linda M Zangwill; Erwin R Boer; Robert N Weinreb; Felipe A Medeiros Journal: JAMA Ophthalmol Date: 2015-04 Impact factor: 7.389
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Authors: Alberto Diniz-Filho; Ricardo Y Abe; Hyong Jin Cho; Saif Baig; Carolina P B Gracitelli; Felipe A Medeiros Journal: Ophthalmology Date: 2016-02-23 Impact factor: 12.079
Authors: Ricardo Y Abe; Alberto Diniz-Filho; Vital P Costa; Zhichao Wu; Felipe A Medeiros Journal: Ophthalmology Date: 2017-10-13 Impact factor: 12.079
Authors: Ricardo Y Abe; Carolina P B Gracitelli; Alberto Diniz-Filho; Linda M Zangwill; Robert N Weinreb; Felipe A Medeiros Journal: Am J Ophthalmol Date: 2015-04-11 Impact factor: 5.258