Ania M Jastreboff1, Rajita Sinha2, Cheryl M Lacadie3, Iris M Balodis4, Robert Sherwin1, Marc N Potenza5. 1. Department of Internal Medicine, Division of Endocrinology, Yale University School of Medicine, New Haven, CT, USA. 2. Department of Psychiatry Yale University School of Medicine, New Haven, CT, USA; Child Study Center, Yale University School of Medicine, New Haven, CT, USA; Department of Neurobiology, Yale University School of Medicine, New Haven, CT, USA. 3. Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA. 4. Department of Psychiatry Yale University School of Medicine, New Haven, CT, USA. 5. Department of Psychiatry Yale University School of Medicine, New Haven, CT, USA; Child Study Center, Yale University School of Medicine, New Haven, CT, USA; Department of Neurobiology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: marc.potenza@yale.edu.
Abstract
BACKGROUND: Although tobacco-smoking is associated with relatively leaner body mass and smoking cessation with weight gain, the brain mechanisms underlying these relationships are not well understood. Smokers compared to non-smokers have shown diminished neural responses to non-tobacco rewarding stimuli (e.g., monetary rewards), but brain responses to favorite-food cues have not been investigated relative to smoking status. We hypothesized that smokers would exhibit diminished neural responses compared to non-smokers in response to favorite-food cues in motivation-reward and emotion-regulating regions of the brain. METHODS: Twenty-three smokers and 23 non-smokers matched based on body mass index (BMI), age, and gender listened to personalized favorite-food cue, stress, and neutral-relaxing audiotapes during fMRI. RESULTS: During favorite-food cue exposure, smokers versus non-smokers exhibited diminished activations in the caudate, putamen, insula, and thalamus. Neural responses during stress and neutral-relaxing conditions were similar across groups. Subjective food-craving ratings were similar across groups. CONCLUSIONS: The relatively diminished neural responses to favorite-food cues in smokers may contribute to lower BMI.
BACKGROUND: Although tobacco-smoking is associated with relatively leaner body mass and smoking cessation with weight gain, the brain mechanisms underlying these relationships are not well understood. Smokers compared to non-smokers have shown diminished neural responses to non-tobacco rewarding stimuli (e.g., monetary rewards), but brain responses to favorite-food cues have not been investigated relative to smoking status. We hypothesized that smokers would exhibit diminished neural responses compared to non-smokers in response to favorite-food cues in motivation-reward and emotion-regulating regions of the brain. METHODS: Twenty-three smokers and 23 non-smokers matched based on body mass index (BMI), age, and gender listened to personalized favorite-food cue, stress, and neutral-relaxing audiotapes during fMRI. RESULTS: During favorite-food cue exposure, smokers versus non-smokers exhibited diminished activations in the caudate, putamen, insula, and thalamus. Neural responses during stress and neutral-relaxing conditions were similar across groups. Subjective food-craving ratings were similar across groups. CONCLUSIONS: The relatively diminished neural responses to favorite-food cues in smokers may contribute to lower BMI.
Authors: Matthew M Clark; Paul A Decker; Kenneth P Offord; Christi A Patten; Kristin S Vickers; Ivana T Croghan; J Taylor Hays; Richard D Hurt; Lowell C Dale Journal: Addict Behav Date: 2004-11 Impact factor: 3.913
Authors: Sarah W Yip; Elise B Potenza; Iris M Balodis; Cheryl M Lacadie; Rajita Sinha; Linda C Mayes; Marc N Potenza Journal: Neuropsychopharmacology Date: 2014-06-06 Impact factor: 7.853
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