| Literature DB >> 25442310 |
Tuyet Anh Dang Thi1, Nguyen Thi Kim Tuyet1, Chinh Pham The1, Ha Thanh Nguyen1, Cham Ba Thi1, Tien Doan Duy1, Matthias D'hooghe2, Tuyen Van Nguyen3.
Abstract
Betulinic acid and analogous naturally occurring triterpenoid acids were transformed into the corresponding propargyl esters and subsequently deployed as substrates for a click chemistry-mediated coupling with azidothymidine (AZT) en route to novel 1,2,3-triazole-tethered triterpenoid-AZT conjugates. Twelve new hybrids were thus prepared and assessed in terms of their cytotoxic activity, revealing an interesting anticancer activity of five triterpenoid-AZT hybrids on KB and Hep-G2 tumor cell lines.Entities:
Keywords: AZT; Cytotoxic agents; Hybrids; Triterpenoids
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Year: 2014 PMID： 25442310 DOI： 10.1016/j.bmcl.2014.09.079
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823