Cristina Veres1, Rodrigue S Allodji1, Damien Llanas1, Jérémi Vu Bezin1, Jean Chavaudra2, Jean Pierre Mège2, Dimitri Lefkopoulos2, Eric Quiniou3, Eric Deutsh4, Florent de Vathaire1, Ibrahima Diallo5. 1. Radiation Epidemiology Group, Center for Research in Epidemiology and Population Health, Institut National de la Santé et de la Recherche Médicale, UMR 1018, Villejuif, France; Institut Gustave Roussy, Villejuif, France; University Paris-Sud XI, Villejuif, France. 2. Institut Gustave Roussy, Villejuif, France. 3. Institut National de la Santé et de la Recherche Médicale UMR 759, Orsay, France. 4. Institut Gustave Roussy, Villejuif, France; Institut National de la Santé et de la Recherche Médicale, UMR 1030, Villejuif, France. 5. Radiation Epidemiology Group, Center for Research in Epidemiology and Population Health, Institut National de la Santé et de la Recherche Médicale, UMR 1018, Villejuif, France; Institut Gustave Roussy, Villejuif, France; University Paris-Sud XI, Villejuif, France. Electronic address: ibrahim.diallo@gustaveroussy.fr.
Abstract
PURPOSE: To present a method for calculating dose-volume histograms (DVH's) to the active bone marrow (ABM) of patients who had undergone radiation therapy (RT) and subsequently developed leukemia. METHODS AND MATERIALS: The study focuses on 15 patients treated between 1961 and 1996. Whole-body RT planning computed tomographic (CT) data were not available. We therefore generated representative whole-body CTs similar to patient anatomy. In addition, we developed a method enabling us to obtain information on the density distribution of ABM all over the skeleton. Dose could then be calculated in a series of points distributed all over the skeleton in such a way that their local density reflected age-specific data for ABM distribution. Dose to particular regions and dose-volume histograms of the entire ABM were estimated for all patients. RESULTS: Depending on patient age, the total number of dose calculation points generated ranged from 1,190,970 to 4,108,524. The average dose to ABM ranged from 0.3 to 16.4 Gy. Dose-volume histograms analysis showed that the median doses (D50%) ranged from 0.06 to 12.8 Gy. We also evaluated the inhomogeneity of individual patient ABM dose distribution according to clinical situation. It was evident that the coefficient of variation of the dose for the whole ABM ranged from 1.0 to 5.7, which means that the standard deviation could be more than 5 times higher than the mean. CONCLUSIONS: For patients with available long-term follow-up data, our method provides reconstruction of dose-volume data comparable to detailed dose calculations, which have become standard in modern CT-based 3-dimensional RT planning. Our strategy of using dose-volume histograms offers new perspectives to retrospective epidemiological studies.
PURPOSE: To present a method for calculating dose-volume histograms (DVH's) to the active bone marrow (ABM) of patients who had undergone radiation therapy (RT) and subsequently developed leukemia. METHODS AND MATERIALS: The study focuses on 15 patients treated between 1961 and 1996. Whole-body RT planning computed tomographic (CT) data were not available. We therefore generated representative whole-body CTs similar to patient anatomy. In addition, we developed a method enabling us to obtain information on the density distribution of ABM all over the skeleton. Dose could then be calculated in a series of points distributed all over the skeleton in such a way that their local density reflected age-specific data for ABM distribution. Dose to particular regions and dose-volume histograms of the entire ABM were estimated for all patients. RESULTS: Depending on patient age, the total number of dose calculation points generated ranged from 1,190,970 to 4,108,524. The average dose to ABM ranged from 0.3 to 16.4 Gy. Dose-volume histograms analysis showed that the median doses (D50%) ranged from 0.06 to 12.8 Gy. We also evaluated the inhomogeneity of individual patient ABM dose distribution according to clinical situation. It was evident that the coefficient of variation of the dose for the whole ABM ranged from 1.0 to 5.7, which means that the standard deviation could be more than 5 times higher than the mean. CONCLUSIONS: For patients with available long-term follow-up data, our method provides reconstruction of dose-volume data comparable to detailed dose calculations, which have become standard in modern CT-based 3-dimensional RT planning. Our strategy of using dose-volume histograms offers new perspectives to retrospective epidemiological studies.
Authors: Ziyuan Wang; Marco Virgolin; Peter A N Bosman; Koen F Crama; Brian V Balgobind; Arjan Bel; Tanja Alderliesten Journal: J Med Imaging (Bellingham) Date: 2020-02-03
Authors: Luke Arentsen; Karen E Hansen; Masashi Yagi; Yutaka Takahashi; Ryan Shanley; Angela McArthur; Patrick Bolan; Taiki Magome; Douglas Yee; Jerry Froelich; Susanta K Hui Journal: J Bone Miner Metab Date: 2016-12-09 Impact factor: 2.626
Authors: Nicola S Russell; Inge M Krul; Anna M van Eggermond; Berthe M P Aleman; Rosie Cooke; Susanne Kuiper; Steven D Allen; Matthew G Wallis; Damien Llanas; Ibrahima Diallo; Florent de Vathaire; Susan A Smith; Michael Hauptmann; Annegien Broeks; Anthony J Swerdlow; Flora E Van Leeuwen Journal: Clin Transl Radiat Oncol Date: 2017-10-24
Authors: Rodrigue S Allodji; Margaret A Tucker; Michael M Hawkins; Marie-Cécile Le Deley; Cristina Veres; Rita Weathers; Rebecca Howell; Dave Winter; Nadia Haddy; Carole Rubino; Ibrahima Diallo; Mark P Little; Lindsay M Morton; Florent de Vathaire Journal: Int J Cancer Date: 2020-11-09 Impact factor: 7.316