Bone morphogenetic proteins: indications and uses.

The BMPs are a group of growth factors that have varied roles in the development and maintenance of many organ systems. Several of the BMPs have osteogenic potential, and exert their effects via complex and highly regulated pathways. At present, only rhBMP-2 and rhBMP-7 are available for clinical use, but only rhBMP-2 is readily available, and from a practical standpoint is considered the only commercially available BMP. Only a few studies exist on BMP use in foot and ankle surgery, but these have shown promising results with low complication rates. BMP is an adjuvant to bone healing,and does not substitute for structural bone needs. In addition, rhBMP-2 outside spinal fusions is considered to be US Food and Drug Administration off-label, and should be used only in patients who are at high risk for bone healing problems.