| Literature DB >> 25439878 |
Elizângela A M S Almeida1, Suelen P Facchi2, Alessandro F Martins3, Samara Nocchi4, Ivânia T A Schuquel1, Celso V Nakamura4, Adley F Rubira1, Edvani C Muniz1.
Abstract
New pectin derivative (Pec-MA) was obtained in specific reaction conditions. The presence of maleoyl groups in Pec-MA structure was confirmed by (1)H NMR and FTIR spectroscopy. The substitution degree of Pec-MA (DS=24%) was determined by (1)H NMR. The properties of Pec-MA were investigated through WAXS, TGA/DTG, SEM and zeta potential techniques. The Pec-MA presented amorphous characteristics and higher-thermal stability compared to raw pectin (Pec). In addition, considerable morphological differences between Pec-MA and Pec were observed by SEM. The cytotoxic effect on the Caco-2 cells showed that the Pec-MA significantly inhibited the growth of colon cancer cells whereas the Pec-MA does not show any cytotoxic effect on the VERO healthy cells. This result opens new perspectives for the manufacture of biomaterials based on Pec with anti-tumor properties.Entities:
Keywords: Antitumor property; Biopolymers; Caco-2 cells; Pectin; Pectin derivative; Vero cells
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Year: 2014 PMID： 25439878 DOI： 10.1016/j.carbpol.2014.08.085
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381