Brian O'Donoghue1, Barnaby Nelson2, Hok Pan Yuen2, Abbie Lane3, Stephen Wood4, Andrew Thompson5, Ashleigh Lin5, Patrick McGorry2, Alison R Yung6. 1. Orygen Youth Health Research Centre, 35 Poplar rd, Parkville, Victoria, Australia; University College Dublin, Belfield, Dublin 4, Ireland; Division of Mental Health and Wellbeing, University of Warwick, UK. Electronic address: briannoelodonoghue@gmail.com. 2. Orygen Youth Health Research Centre, 35 Poplar rd, Parkville, Victoria, Australia; University of Melbourne, Parkville, Victoria, Australia. 3. University College Dublin, Belfield, Dublin 4, Ireland. 4. School of Psychology, University of Birmingham, Birmingham, UK; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Victoria, Australia. 5. Telethon Kids Institute, The University of Western Australia, Australia. 6. Orygen Youth Health Research Centre, 35 Poplar rd, Parkville, Victoria, Australia; Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.
Abstract
OBJECTIVE: Despite social environmental factors such as deprivation, urbanicity, migration and adversity being established risk factors for psychotic disorders, there is a paucity of knowledge on the influence of social environmental risk factors in the UHR population. Firstly, we aimed to investigate the association between social deprivation and risk of transition and secondly, we aimed to investigate the association between migration status and the risk of transition. METHOD: UHR individuals at the Personal Assessment and Crisis Evaluation (PACE) service in Melbourne were included. Social deprivation as assessed according to postal code area of residence was obtained from census data and Cox regression analysis was used to calculate hazard ratios. RESULTS: A total of 219 UHR individuals were included and over the median follow-up time of 4.8years, 32 individuals (14.6%) were known to have transitioned to a psychotic disorder. 8.8% of UHR individuals were first generation migrants and 41.9% were second generation migrants. The level of social deprivation was not associated with the risk of transition (p=0.83). Similarly, first or second generation migrants did not have an increased risk of transition to psychosis (p=0.84). CONCLUSIONS: Despite being established risk factors for psychotic disorders, social deprivation and migrant status have not been found to increase the risk of transition in a UHR population.
OBJECTIVE: Despite social environmental factors such as deprivation, urbanicity, migration and adversity being established risk factors for psychotic disorders, there is a paucity of knowledge on the influence of social environmental risk factors in the UHR population. Firstly, we aimed to investigate the association between social deprivation and risk of transition and secondly, we aimed to investigate the association between migration status and the risk of transition. METHOD: UHR individuals at the Personal Assessment and Crisis Evaluation (PACE) service in Melbourne were included. Social deprivation as assessed according to postal code area of residence was obtained from census data and Cox regression analysis was used to calculate hazard ratios. RESULTS: A total of 219 UHR individuals were included and over the median follow-up time of 4.8years, 32 individuals (14.6%) were known to have transitioned to a psychotic disorder. 8.8% of UHR individuals were first generation migrants and 41.9% were second generation migrants. The level of social deprivation was not associated with the risk of transition (p=0.83). Similarly, first or second generation migrants did not have an increased risk of transition to psychosis (p=0.84). CONCLUSIONS: Despite being established risk factors for psychotic disorders, social deprivation and migrant status have not been found to increase the risk of transition in a UHR population.
Authors: Brian O'Donoghue; Hellen Geros; Holly Sizer; Jean Addington; G Paul Amminger; Carrie E Beaden; Kristin S Cadenhead; Tyrone D Cannon; Barbara A Cornblatt; Gregor Emanuel Berger; Eric Y H Chen; Lieuwe de Haan; Jessica A Hartmann; Ian B Hickie; Helga K Ising; Suzie Lavoie; Ashleigh Lin; Connie Markulev; Daniel H Mathalon; Thomas H McGlashan; Nathan G Mifsud; Nilufar Mossaheb; Dorien H Nieman; Merete Nordentoft; Diana O Perkins; Anita Riecher-Rössler; Miriam R Schäfer; Monika Schlögelhofer; Larry J Seidman; Stephan Smesny; Andrew Thompson; Ming T Tsuang; Mark van der Gaag; Swapna Verma; Elaine F Walker; Stephen J Wood; Scott W Woods; Hok Pan Yuen; Alison Ruth Yung; Patrick D McGorry; Barnaby Nelson Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2021-01-05 Impact factor: 4.328
Authors: Arthur S Nogueira; Julio C Andrade; Mauricio H Serpa; Tania M Alves; Elder L Freitas; Lucas Hortêncio; Martinus T van de Bilt; Wulf Rössler; Wagner F Gattaz; Alexandre A Loch Journal: Braz J Psychiatry Date: 2020-08-03 Impact factor: 2.697
Authors: Katarzyna Waszczuk; Ernest Tyburski; Katarzyna Rek-Owodziń; Piotr Plichta; Krzysztof Rudkowski; Piotr Podwalski; Maksymilian Bielecki; Monika Mak; Adrianna Bober; Błażej Misiak; Leszek Sagan; Anna Michalczyk; Jolanta Kucharska-Mazur; Jerzy Samochowiec Journal: Brain Sci Date: 2022-03-07