F B Schuch1, M P Vasconcelos-Moreno2, C Borowsky3, A B Zimmermann2, N S Rocha2, M P Fleck2. 1. Post-graduate Program in Medical Sciences: Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Department of Psychiatry, Clinics Hospital of Porto Alegre, Porto Alegre, Brazil. Electronic address: felipe.schuch@ufrgs.br. 2. Post-graduate Program in Medical Sciences: Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Department of Psychiatry, Clinics Hospital of Porto Alegre, Porto Alegre, Brazil. 3. Department of Psychiatry, Clinics Hospital of Porto Alegre, Porto Alegre, Brazil.
Abstract
BACKGROUND: Exercise is a potential treatment for depression. However, few studies have evaluated the role of adjunct exercise in the treatment of severely major depressed inpatients. The goal of this study was to evaluate the effects of add-on exercise on the usual treatment of severely depressed inpatients. METHODS:Fifty participants were randomized to an exercise (exercise + usual treatment) or a control (usual treatment) group. Twenty-five patients were randomly allocated to each group. The participants in the exercise group performed three sessions per week throughout the hospitalization period, with a goal dose of 16.5 kcal/kg/week plus the usual pharmacological treatment. Depressive symptoms and the Quality of Life (QoL) of the participants were assessed at the baseline, the second week, and discharge. RESULTS: A significant group × time interaction was found for depressive symptoms and the physical and psychological domains of QoL. Differences between groups occurred at the second week and discharge with respect to depressive symptoms and the physical and psychological domains of QoL. There was no difference in the remission rate at discharge (48% and 32% for the exercise and control group, respectively). An NNT of 6.25 was found. No significant baseline characteristics predict remission at discharge. CONCLUSION: Add-on exercise is an efficacious treatment for severely depressed inpatients, improving their depressive symptoms and QoL. Initial acceptance of exercise remains a challenge.
RCT Entities:
BACKGROUND: Exercise is a potential treatment for depression. However, few studies have evaluated the role of adjunct exercise in the treatment of severely major depressed inpatients. The goal of this study was to evaluate the effects of add-on exercise on the usual treatment of severely depressed inpatients. METHODS: Fifty participants were randomized to an exercise (exercise + usual treatment) or a control (usual treatment) group. Twenty-five patients were randomly allocated to each group. The participants in the exercise group performed three sessions per week throughout the hospitalization period, with a goal dose of 16.5 kcal/kg/week plus the usual pharmacological treatment. Depressive symptoms and the Quality of Life (QoL) of the participants were assessed at the baseline, the second week, and discharge. RESULTS: A significant group × time interaction was found for depressive symptoms and the physical and psychological domains of QoL. Differences between groups occurred at the second week and discharge with respect to depressive symptoms and the physical and psychological domains of QoL. There was no difference in the remission rate at discharge (48% and 32% for the exercise and control group, respectively). An NNT of 6.25 was found. No significant baseline characteristics predict remission at discharge. CONCLUSION: Add-on exercise is an efficacious treatment for severely depressed inpatients, improving their depressive symptoms and QoL. Initial acceptance of exercise remains a challenge.
Authors: Tracy L Greer; Joseph M Trombello; Chad D Rethorst; Thomas J Carmody; Manish K Jha; Allen Liao; Bruce D Grannemann; Heather O Chambliss; Timothy S Church; Madhukar H Trivedi Journal: Depress Anxiety Date: 2016-05-10 Impact factor: 6.505
Authors: Lara F Carneiro; Maria P Mota; Felipe Schuch; Andrea Deslandes; José Vasconcelos-Raposo Journal: Braz J Psychiatry Date: 2017-08-30 Impact factor: 2.697
Authors: Davy Vancampfort; Simon Rosenbaum; Felipe Schuch; Philip B Ward; Justin Richards; James Mugisha; Michel Probst; Brendon Stubbs Journal: Sports Med Date: 2017-02 Impact factor: 11.136
Authors: Brendon Stubbs; Davy Vancampfort; Simon Rosenbaum; Philip B Ward; Justin Richards; Michael Ussher; Felipe B Schuch Journal: Sports Med Date: 2016-05 Impact factor: 11.136
Authors: Mami Shibata; Julius Burkauskas; Artemisa R Dores; Kei Kobayashi; Sayaka Yoshimura; Pierluigi Simonato; Ilaria De Luca; Dorotea Cicconcelli; Valentina Giorgetti; Irene P Carvalho; Fernando Barbosa; Cristina Monteiro; Toshiya Murai; Maria A Gómez-Martínez; Zsolt Demetrovics; Krisztina Edina Ábel; Attila Szabo; Alejandra Rebeca Melero Ventola; Eva Maria Arroyo-Anlló; Ricardo M Santos-Labrador; Inga Griskova-Bulanova; Aiste Pranckeviciene; Giuseppe Bersani; Hironobu Fujiwara; Ornella Corazza Journal: Front Psychol Date: 2021-07-06