Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Stochastic variations of migration speed between cells in clonal populations.

Literature DB >> 25436220

Stochastic variations of migration speed between cells in clonal populations.

Abstract

We combined microfluidic tools and molecular probes to monitor the migration speed of successive generations of cancer cells. We found that the migratory speed of individual cells changes stochastically from parent cells to their descendants, while the average speed of successive generations of cells remains constant. Further studies of the interrelations between cell migration and division processes may help identify the molecular determinants of cell speed and lead to new therapies to slow the invasion of cancer cells and delay metastases.

Entities: CellLine Chemical Disease Gene Species

Year: 2014 PMID： 25436220 PMCID： PMC4245034 DOI： 10.1142/S2339547814200027

Source DB: PubMed Journal: Technology (Singap World Sci)

17 in total

1. Control of stochasticity in eukaryotic gene expression.

Authors: Jonathan M Raser; Erin K O'Shea
Journal: Science Date: 2004-05-27 Impact factor: 47.728

2. Asymmetric cancer cell division regulated by AKT.

Authors: Ipsita Dey-Guha; Anita Wolfer; Albert C Yeh; John G Albeck; Revati Darp; Eduardo Leon; Julia Wulfkuhle; Emanuel F Petricoin; Ben S Wittner; Sridhar Ramaswamy
Journal: Proc Natl Acad Sci U S A Date: 2011-07-14 Impact factor: 11.205

3. Stochastic protein expression in individual cells at the single molecule level.

Authors: Long Cai; Nir Friedman; X Sunney Xie
Journal: Nature Date: 2006-03-16 Impact factor: 49.962

4. Adaptive-control model for neutrophil orientation in the direction of chemical gradients.

Authors: Daniel Irimia; Gábor Balázsi; Nitin Agrawal; Mehmet Toner
Journal: Biophys J Date: 2009-05-20 Impact factor: 4.033

5. Migration of brain tumor cells on extracellular matrix proteins in vitro correlates with tumor type and grade and involves alphaV and beta1 integrins.

Authors: D R Friedlander; D Zagzag; B Shiff; H Cohen; J C Allen; P J Kelly; M Grumet
Journal: Cancer Res Date: 1996-04-15 Impact factor: 12.701

6. Growth and metastasis of hypermotile, hyperinvasive cancer cells selected in vitro by rapid locomotion under various conditions.

Authors: I A Grimstad
Journal: Clin Exp Metastasis Date: 1988 Jul-Aug Impact factor: 5.150

7. Direct evidence that cancer cell locomotion contributes importantly to invasion.

Authors: I A Grimstad
Journal: Exp Cell Res Date: 1987-12 Impact factor: 3.905

Review 8. Hallmarks of cancer: the next generation.

Authors: Douglas Hanahan; Robert A Weinberg
Journal: Cell Date: 2011-03-04 Impact factor: 41.582

9. Stochastic cytokine expression induces mixed T helper cell States.

Authors: Miaoqing Fang; Huangming Xie; Stephanie K Dougan; Hidde Ploegh; Alexander van Oudenaarden
Journal: PLoS Biol Date: 2013-07-30 Impact factor: 8.029

10. Cooperative roles of SDF-1α and EGF gradients on tumor cell migration revealed by a robust 3D microfluidic model.

Authors: Beum Jun Kim; Pimkhuan Hannanta-anan; Michelle Chau; Yoon Soo Kim; Melody A Swartz; Mingming Wu
Journal: PLoS One Date: 2013-07-15 Impact factor: 3.240

4 in total

1. Cell Sequence and Mitosis Affect Fibroblast Directional Decision-Making During Chemotaxis in Microfluidic Mazes.

Authors: Quang Long Pham; Lydia N Rodrigues; Max A Maximov; Vishnu Deep Chandran; Cheng Bi; David Chege; Timothy Dijamco; Elisabeth Stein; Nhat Anh Nguyen Tong; Sagnik Basuray; Roman S Voronov
Journal: Cell Mol Bioeng Date: 2018-08-27 Impact factor: 2.321