Jing Bai1, Xiang Ding1, Xiaohui Du1, Xiangfeng Zhao1, Zhiquan Wang2, Zhiqiang Ma3. 1. Department of Cardiology of PLA 161 Hospital, Wuhan 430030, China. 2. Department of Cardiology of PLA 161 Hospital, Wuhan 430030, China. Electronic address: wzq161@hotmail.com. 3. Department of Cardiology of PLA 161 Hospital, Wuhan 430030, China. Electronic address: mzqy1967@tom.com.
Abstract
AIMS: Increasing evidence suggests an association between diabetes and risk of venous thromboembolism (VTE); however, the results are inconsistent. We conducted a systematic review and meta-analysis of all epidemiological evidence to clarify association of diabetes with risk of VTE. METHODS: We searched MEDLINE and EMBASE to retrieve all relevant articles. Pooled effect estimates were calculated through a random-effects model. RESULTS: Sixteen articles involving 803,627,121 participants and 10,429,227 VTE patients were included. Pooled analysis of all evidence suggested that diabetes was associated with increased risk of VTE (HR, 1.35; 95%CI, 1.17-1.55; p=2.92*10(-5)), with evidence of small-study effect (p=0.024) and heterogeneity (I(2)=87.1%, p<0.001). However, when analysis was restricted to high quality cohort studies, the association remained significantly (HR, 1.36; 95%CI 1.11-1.68; p=0.004), with no evidence of publication bias (p=0.192) and heterogeneity (I(2)=23.2%, p=0.245). CONCLUSIONS: Diabetes is associated with increased risk of VTE, which may have implications for the primary and secondary prevention of VTE.
AIMS: Increasing evidence suggests an association between diabetes and risk of venous thromboembolism (VTE); however, the results are inconsistent. We conducted a systematic review and meta-analysis of all epidemiological evidence to clarify association of diabetes with risk of VTE. METHODS: We searched MEDLINE and EMBASE to retrieve all relevant articles. Pooled effect estimates were calculated through a random-effects model. RESULTS: Sixteen articles involving 803,627,121 participants and 10,429,227 VTEpatients were included. Pooled analysis of all evidence suggested that diabetes was associated with increased risk of VTE (HR, 1.35; 95%CI, 1.17-1.55; p=2.92*10(-5)), with evidence of small-study effect (p=0.024) and heterogeneity (I(2)=87.1%, p<0.001). However, when analysis was restricted to high quality cohort studies, the association remained significantly (HR, 1.36; 95%CI 1.11-1.68; p=0.004), with no evidence of publication bias (p=0.192) and heterogeneity (I(2)=23.2%, p=0.245). CONCLUSIONS:Diabetes is associated with increased risk of VTE, which may have implications for the primary and secondary prevention of VTE.
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